Zygomycetes hyphae trigger an early, robust proinflammatory response in human polymorphonuclear neutrophils through toll-like receptor 2 induction but display relative resistance to oxidative damage

G. Chamilos, R. E. Lewis, G. Lamaris, T. J. Walsh, D. P. Kontoyiannis

Research output: Contribution to journalArticlepeer-review

Abstract

Human polymorphonuclear neutrophils (HPMNs) displayed attenuated hyphal damage associated with impaired O2- release following exposure to Rhizopus oryzae versus that with Aspergillus fumigatus. Exposure of HPMNs to R. oryzae hyphae resulted in upregulation in Toll-like receptor 2 mRNA and a robust proinflammatory gene expression with rapid (1-h) induction of NF-κB pathway-related genes.

Original languageEnglish (US)
Pages (from-to)722-724
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume52
Issue number2
DOIs
StatePublished - Feb 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Zygomycetes hyphae trigger an early, robust proinflammatory response in human polymorphonuclear neutrophils through toll-like receptor 2 induction but display relative resistance to oxidative damage'. Together they form a unique fingerprint.

Cite this