Zone of transition: A potential source of error in tumor volume estimation

Lijuan Zhang, David F. Yankelevitz, Claudia I. Henschke, Artit C. Jirapatnakul, Anthony P. Reeves, Darryl Carter

Research output: Contribution to journalArticle

Abstract

Purpose: To measure the width of the zone of transition (ZOT) between nonaerated solid tumor and surrounding nonneoplastic lung parenchyma and determine the extent to which ZOT influences computer-derived estimates of tumor volume based on computed tomographic (CT) images. Materials and Methods: This HIPAA-compliant study was approved by the institutional research board. The histologic slide containing the maximum tumor area was digitized for 20 consecutive patients with solid adenocarcinoma. The outer border of the tumor (A2) was marked; it included all lung parenchyma having any tumor cells. The inner border of the tumor (A1) was marked; it included only solid tumor where lung parenchyma was no longer preserved. Assuming two circles with areas of A2 and A1, the corresponding two radii, R2 and R1, were calculated. The average width of the ZOT was defined as R2 minus R1. The relationship between ZOT and tumor diameter on the CT images prior to surgery was assessed by using regression analysis. The relationship between ZOT and tumor volume was assessed by using a theoretical model of idealized spheres with varying diameters. Results: The mean width of the ZOT was 0.78 mm (median, 0.48 mm). The proportional effect of ZOT on tumor volume estimates decreased with increasing tumor diameter and increased with increasing width of ZOT. Correlation between ZOT and tumor diameter was not significant ( P = .87). Conclusion: The average width of ZOT is about a single pixel width on a full field of view CT scan; thus, the ZOT can have a large effect on volume estimates, particularly for small tumors.

Original languageEnglish (US)
Pages (from-to)633-639
Number of pages7
JournalRadiology
Volume256
Issue number2
DOIs
StatePublished - 2010
Externally publishedYes

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Tumor Burden
Research Design
Neoplasms
varespladib methyl
Lung
Health Insurance Portability and Accountability Act
Adenocarcinoma
Theoretical Models
Regression Analysis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Zhang, L., Yankelevitz, D. F., Henschke, C. I., Jirapatnakul, A. C., Reeves, A. P., & Carter, D. (2010). Zone of transition: A potential source of error in tumor volume estimation. Radiology, 256(2), 633-639. https://doi.org/10.1148/radiol.10090924

Zone of transition : A potential source of error in tumor volume estimation. / Zhang, Lijuan; Yankelevitz, David F.; Henschke, Claudia I.; Jirapatnakul, Artit C.; Reeves, Anthony P.; Carter, Darryl.

In: Radiology, Vol. 256, No. 2, 2010, p. 633-639.

Research output: Contribution to journalArticle

Zhang, L, Yankelevitz, DF, Henschke, CI, Jirapatnakul, AC, Reeves, AP & Carter, D 2010, 'Zone of transition: A potential source of error in tumor volume estimation', Radiology, vol. 256, no. 2, pp. 633-639. https://doi.org/10.1148/radiol.10090924
Zhang L, Yankelevitz DF, Henschke CI, Jirapatnakul AC, Reeves AP, Carter D. Zone of transition: A potential source of error in tumor volume estimation. Radiology. 2010;256(2):633-639. https://doi.org/10.1148/radiol.10090924
Zhang, Lijuan ; Yankelevitz, David F. ; Henschke, Claudia I. ; Jirapatnakul, Artit C. ; Reeves, Anthony P. ; Carter, Darryl. / Zone of transition : A potential source of error in tumor volume estimation. In: Radiology. 2010 ; Vol. 256, No. 2. pp. 633-639.
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