Zollinger Ellison syndrome. Ultrastructural and histochemical observations in a child with endocrine tumorlets of gastric antrum

B. S. Bhagavan, Gerald A. Hofkin, G. M. Woel, L. G. Koss

Research output: Contribution to journalArticlepeer-review

Abstract

A case of Zollinger Ellison syndrome associated with multifocal hyperplasia (tumorlets) of gastric antral argyrophillic cells was found in an 11 yr old boy. Similar tumorlets were present in the resected proximal duodenum. Histochemical and ultrastructural features indicate that the component cells of the tumorlets had many features characteristic of gastrin containing ''G cells''. There was no evidence of abnormality within the subtotally resected pancreas. Persistent postoperative hypergastrinemia and hyperserotoninemia is thought to be related to residual tumorlets in the part of the duodenum or jejunum left in situ.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalArchives of Pathology and Laboratory Medicine
Volume98
Issue number4
StatePublished - Dec 1 1974

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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