Zn2+ potentiates steady-state ATP activated currents in rat nodose ganglion neurons by increasing the burst duration of a 35 pS channel

Jerry M. Wright, Chaoying Li

Research output: Contribution to journalArticle

Abstract

Zn2+ and ATP are normally present in serum at low levels and are released from some neurons during synaptic activity. In whole-cell recordings, 10 μM Zn2+ potentiated steady-state currents in rat nodose ganglion nerve cells by 18% in 0.5 μM ATP and 120% in 2 μM ATP. Fluctuation analysis of whole-cell currents suggested the mechanism was increased burst duration. In single-channel recordings, 10 μM Zn2+ did not increase the ATP-activated channel conductance but did increase the mean burst duration of the 35 pS primary open conductance state. These observations indicate that Zn2+ potentiates the steady-state response to extracellular ATP by increasing the burst duration of the channels.

Original languageEnglish (US)
Pages (from-to)177-180
Number of pages4
JournalNeuroscience Letters
Volume193
Issue number3
DOIs
StatePublished - Jul 7 1995
Externally publishedYes

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Nodose Ganglion
Adenosine Triphosphate
Neurons
Patch-Clamp Techniques
Serum

Keywords

  • ATP-activated channel
  • Nodose ganglion
  • Noise analysis
  • Single-channel recording
  • Whole-cell recording
  • Zinc

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Zn2+ potentiates steady-state ATP activated currents in rat nodose ganglion neurons by increasing the burst duration of a 35 pS channel. / Wright, Jerry M.; Li, Chaoying.

In: Neuroscience Letters, Vol. 193, No. 3, 07.07.1995, p. 177-180.

Research output: Contribution to journalArticle

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