Zinc treatment for 5 or 10 days is equally efficacious in preventing diarrhea in the subsequent 3 months among Bangladeshi children

Dewan S. Alam, Mohammad Yunus, Shams El Arifeen, Hafizur R. Chowdury, Charles P. Larson, David Allen Sack, Abdullah Baqui, Robert E Black

Research output: Contribution to journalArticle

Abstract

We conducted a randomized, double-blind placebo controlled, community trial in rural Bangladesh in children 4-59 mo of age to compare the efficacy of a 5- and 10-d course of zinc therapy on the incidence and duration of diarrhea over the subsequent 90-d follow-up after initial treatment for an acute childhood diarrheal (ACD) episode. Children (n = 1622) with ACD were randomly allocated to either 5 or 10 d of zinc treatment. Female field workers visited each child daily, supervised the administration of zinc, recorded the duration of current episode, and the occurrence and duration of diarrhea over the subsequent 3mo. The incidence of diarrhea over the 90 d of follow-up did not differ between the 5-d (1.08 ± 1.38 episodes) and 10-d (1.02 ± 1.35 episodes) groups (P = 0.35). Children in both groups experienced a comparable duration of diarrheal episodes (3.1 ± 5.6 d vs. 2.9 ± 5.6 d, 5-d vs. 10-d, respectively; P = 0.64) with a mean difference between groups within the defined range of equivalence. Time to onset of the first episode and the proportion children experiencing diarrhea during the 90-d follow-up also did not differ between groups. These findings suggest that among Bangladeshi children, a 5-d zinc treatment for ACD is as efficacious as 10 d in preventing diarrhea in the subsequent 3 mo.

Original languageEnglish (US)
Pages (from-to)312-315
Number of pages4
JournalJournal of Nutrition
Volume141
Issue number2
DOIs
StatePublished - Feb 1 2011

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Zinc
Diarrhea
Therapeutics
Bangladesh
Incidence
Health Personnel
Placebos

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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Zinc treatment for 5 or 10 days is equally efficacious in preventing diarrhea in the subsequent 3 months among Bangladeshi children. / Alam, Dewan S.; Yunus, Mohammad; El Arifeen, Shams; Chowdury, Hafizur R.; Larson, Charles P.; Sack, David Allen; Baqui, Abdullah; Black, Robert E.

In: Journal of Nutrition, Vol. 141, No. 2, 01.02.2011, p. 312-315.

Research output: Contribution to journalArticle

Alam, Dewan S. ; Yunus, Mohammad ; El Arifeen, Shams ; Chowdury, Hafizur R. ; Larson, Charles P. ; Sack, David Allen ; Baqui, Abdullah ; Black, Robert E. / Zinc treatment for 5 or 10 days is equally efficacious in preventing diarrhea in the subsequent 3 months among Bangladeshi children. In: Journal of Nutrition. 2011 ; Vol. 141, No. 2. pp. 312-315.
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