Zinc toxicity with pancreatic acinar necrosis in piglets receiving total patenteral nutrition

Kathleen L Gabrielson, R. L. Remillard, D. L. Huso

Research output: Contribution to journalArticle

Abstract

Two Hampshire-Duroc cross piglets maintained on 100% total patenterai nutrition (TPN) for 3 weeks developed pancreatic epithelial cell necrosis, diffuse acinar atrophy, and marked interstitial fibrosis. In addition, the piglets had severe villus atrophy in the small intestine as a result of TPN. Atomic absorption spectrophotometric analysis of liver samples revealed toxic hepatic zinc levels (513.5 and 491.2 ppm) in the TPN piglets (40-90 ppm in control piglets). Administering TPN bypasses homeostatic control mechanisms regulating zinc absorption at the gastrointestinal level and may reduce pancreatic secretion contributing to the accumulation of zinc in tissues. Intestinal villus atrophy, a sequela to TPN, may have also affected zinc excretion by impairing intestinal flux and desquamation. These factors should be considered in formulating TPN solutions and zinc levels administered must be reduced accordingly to avoid toxicity. Furthermore, sources and tissue levels of zinc should be investigated when necrosis, acinar atrophy, and fibrosis of the pancreas are encountered in young pigs.

Original languageEnglish (US)
Pages (from-to)692-696
Number of pages5
JournalVeterinary Pathology
Volume33
Issue number6
StatePublished - Nov 1996
Externally publishedYes

Fingerprint

piglets
Zinc
necrosis
Necrosis
zinc
nutrition
toxicity
atrophy
Atrophy
villi
fibrosis
Fibrosis
Hampshire (swine breed)
liver
complications (disease)
Poisons
Liver
Duroc
pancreas
Small Intestine

Keywords

  • Acinar necrosis
  • Pancreas
  • Swine
  • Total parenteral nutrition (TPN)
  • Zinc toxicity

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Zinc toxicity with pancreatic acinar necrosis in piglets receiving total patenteral nutrition. / Gabrielson, Kathleen L; Remillard, R. L.; Huso, D. L.

In: Veterinary Pathology, Vol. 33, No. 6, 11.1996, p. 692-696.

Research output: Contribution to journalArticle

@article{eb5f48ea4e894bb6a64debda7eed0256,
title = "Zinc toxicity with pancreatic acinar necrosis in piglets receiving total patenteral nutrition",
abstract = "Two Hampshire-Duroc cross piglets maintained on 100{\%} total patenterai nutrition (TPN) for 3 weeks developed pancreatic epithelial cell necrosis, diffuse acinar atrophy, and marked interstitial fibrosis. In addition, the piglets had severe villus atrophy in the small intestine as a result of TPN. Atomic absorption spectrophotometric analysis of liver samples revealed toxic hepatic zinc levels (513.5 and 491.2 ppm) in the TPN piglets (40-90 ppm in control piglets). Administering TPN bypasses homeostatic control mechanisms regulating zinc absorption at the gastrointestinal level and may reduce pancreatic secretion contributing to the accumulation of zinc in tissues. Intestinal villus atrophy, a sequela to TPN, may have also affected zinc excretion by impairing intestinal flux and desquamation. These factors should be considered in formulating TPN solutions and zinc levels administered must be reduced accordingly to avoid toxicity. Furthermore, sources and tissue levels of zinc should be investigated when necrosis, acinar atrophy, and fibrosis of the pancreas are encountered in young pigs.",
keywords = "Acinar necrosis, Pancreas, Swine, Total parenteral nutrition (TPN), Zinc toxicity",
author = "Gabrielson, {Kathleen L} and Remillard, {R. L.} and Huso, {D. L.}",
year = "1996",
month = "11",
language = "English (US)",
volume = "33",
pages = "692--696",
journal = "Veterinary Pathology",
issn = "0300-9858",
publisher = "SAGE Publications Ltd",
number = "6",

}

TY - JOUR

T1 - Zinc toxicity with pancreatic acinar necrosis in piglets receiving total patenteral nutrition

AU - Gabrielson, Kathleen L

AU - Remillard, R. L.

AU - Huso, D. L.

PY - 1996/11

Y1 - 1996/11

N2 - Two Hampshire-Duroc cross piglets maintained on 100% total patenterai nutrition (TPN) for 3 weeks developed pancreatic epithelial cell necrosis, diffuse acinar atrophy, and marked interstitial fibrosis. In addition, the piglets had severe villus atrophy in the small intestine as a result of TPN. Atomic absorption spectrophotometric analysis of liver samples revealed toxic hepatic zinc levels (513.5 and 491.2 ppm) in the TPN piglets (40-90 ppm in control piglets). Administering TPN bypasses homeostatic control mechanisms regulating zinc absorption at the gastrointestinal level and may reduce pancreatic secretion contributing to the accumulation of zinc in tissues. Intestinal villus atrophy, a sequela to TPN, may have also affected zinc excretion by impairing intestinal flux and desquamation. These factors should be considered in formulating TPN solutions and zinc levels administered must be reduced accordingly to avoid toxicity. Furthermore, sources and tissue levels of zinc should be investigated when necrosis, acinar atrophy, and fibrosis of the pancreas are encountered in young pigs.

AB - Two Hampshire-Duroc cross piglets maintained on 100% total patenterai nutrition (TPN) for 3 weeks developed pancreatic epithelial cell necrosis, diffuse acinar atrophy, and marked interstitial fibrosis. In addition, the piglets had severe villus atrophy in the small intestine as a result of TPN. Atomic absorption spectrophotometric analysis of liver samples revealed toxic hepatic zinc levels (513.5 and 491.2 ppm) in the TPN piglets (40-90 ppm in control piglets). Administering TPN bypasses homeostatic control mechanisms regulating zinc absorption at the gastrointestinal level and may reduce pancreatic secretion contributing to the accumulation of zinc in tissues. Intestinal villus atrophy, a sequela to TPN, may have also affected zinc excretion by impairing intestinal flux and desquamation. These factors should be considered in formulating TPN solutions and zinc levels administered must be reduced accordingly to avoid toxicity. Furthermore, sources and tissue levels of zinc should be investigated when necrosis, acinar atrophy, and fibrosis of the pancreas are encountered in young pigs.

KW - Acinar necrosis

KW - Pancreas

KW - Swine

KW - Total parenteral nutrition (TPN)

KW - Zinc toxicity

UR - http://www.scopus.com/inward/record.url?scp=0030278879&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030278879&partnerID=8YFLogxK

M3 - Article

C2 - 8952028

AN - SCOPUS:0030278879

VL - 33

SP - 692

EP - 696

JO - Veterinary Pathology

JF - Veterinary Pathology

SN - 0300-9858

IS - 6

ER -