Abstract
Two Hampshire-Duroc cross piglets maintained on 100% total patenterai nutrition (TPN) for 3 weeks developed pancreatic epithelial cell necrosis, diffuse acinar atrophy, and marked interstitial fibrosis. In addition, the piglets had severe villus atrophy in the small intestine as a result of TPN. Atomic absorption spectrophotometric analysis of liver samples revealed toxic hepatic zinc levels (513.5 and 491.2 ppm) in the TPN piglets (40-90 ppm in control piglets). Administering TPN bypasses homeostatic control mechanisms regulating zinc absorption at the gastrointestinal level and may reduce pancreatic secretion contributing to the accumulation of zinc in tissues. Intestinal villus atrophy, a sequela to TPN, may have also affected zinc excretion by impairing intestinal flux and desquamation. These factors should be considered in formulating TPN solutions and zinc levels administered must be reduced accordingly to avoid toxicity. Furthermore, sources and tissue levels of zinc should be investigated when necrosis, acinar atrophy, and fibrosis of the pancreas are encountered in young pigs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 692-696 |
| Number of pages | 5 |
| Journal | Veterinary Pathology |
| Volume | 33 |
| Issue number | 6 |
| State | Published - Nov 1996 |
| Externally published | Yes |
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Keywords
- Acinar necrosis
- Pancreas
- Swine
- Total parenteral nutrition (TPN)
- Zinc toxicity
ASJC Scopus subject areas
- veterinary(all)
Cite this
Zinc toxicity with pancreatic acinar necrosis in piglets receiving total patenteral nutrition. / Gabrielson, Kathleen L; Remillard, R. L.; Huso, D. L.
In: Veterinary Pathology, Vol. 33, No. 6, 11.1996, p. 692-696.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Zinc toxicity with pancreatic acinar necrosis in piglets receiving total patenteral nutrition
AU - Gabrielson, Kathleen L
AU - Remillard, R. L.
AU - Huso, D. L.
PY - 1996/11
Y1 - 1996/11
N2 - Two Hampshire-Duroc cross piglets maintained on 100% total patenterai nutrition (TPN) for 3 weeks developed pancreatic epithelial cell necrosis, diffuse acinar atrophy, and marked interstitial fibrosis. In addition, the piglets had severe villus atrophy in the small intestine as a result of TPN. Atomic absorption spectrophotometric analysis of liver samples revealed toxic hepatic zinc levels (513.5 and 491.2 ppm) in the TPN piglets (40-90 ppm in control piglets). Administering TPN bypasses homeostatic control mechanisms regulating zinc absorption at the gastrointestinal level and may reduce pancreatic secretion contributing to the accumulation of zinc in tissues. Intestinal villus atrophy, a sequela to TPN, may have also affected zinc excretion by impairing intestinal flux and desquamation. These factors should be considered in formulating TPN solutions and zinc levels administered must be reduced accordingly to avoid toxicity. Furthermore, sources and tissue levels of zinc should be investigated when necrosis, acinar atrophy, and fibrosis of the pancreas are encountered in young pigs.
AB - Two Hampshire-Duroc cross piglets maintained on 100% total patenterai nutrition (TPN) for 3 weeks developed pancreatic epithelial cell necrosis, diffuse acinar atrophy, and marked interstitial fibrosis. In addition, the piglets had severe villus atrophy in the small intestine as a result of TPN. Atomic absorption spectrophotometric analysis of liver samples revealed toxic hepatic zinc levels (513.5 and 491.2 ppm) in the TPN piglets (40-90 ppm in control piglets). Administering TPN bypasses homeostatic control mechanisms regulating zinc absorption at the gastrointestinal level and may reduce pancreatic secretion contributing to the accumulation of zinc in tissues. Intestinal villus atrophy, a sequela to TPN, may have also affected zinc excretion by impairing intestinal flux and desquamation. These factors should be considered in formulating TPN solutions and zinc levels administered must be reduced accordingly to avoid toxicity. Furthermore, sources and tissue levels of zinc should be investigated when necrosis, acinar atrophy, and fibrosis of the pancreas are encountered in young pigs.
KW - Acinar necrosis
KW - Pancreas
KW - Swine
KW - Total parenteral nutrition (TPN)
KW - Zinc toxicity
UR - http://www.scopus.com/inward/record.url?scp=0030278879&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030278879&partnerID=8YFLogxK
M3 - Article
C2 - 8952028
AN - SCOPUS:0030278879
VL - 33
SP - 692
EP - 696
JO - Veterinary Pathology
JF - Veterinary Pathology
SN - 0300-9858
IS - 6
ER -