Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: A double-blind, controlled trial

S. Sazawal, Robert E Black, S. Jalla, S. Mazumdar, A. Sinha, M. K. Bhan

Research output: Contribution to journalArticle

Abstract

Background. Increased acute lower respiratory infection incidence, severity, and mortality are associated with malnutrition, and reduced immunological competence may be a mechanism for this association. Because zinc deficiency results in impaired immunocompetence and zinc supplementation improves immune status, we hypothesized that zinc deficiency is associated with increased incidence and severity of acute lower respiratory infection. Methods. We evaluated the effect of daily supplementation with 10 mg of elemental zinc on the incidence and prevalence of acute lower respiratory infection in a double-blind, randomized, controlled trial in 609 children (zinc, n = 298; control, n = 311) 6 to 35 months of age. Supplementation and morbidity surveillance were done for 6 months. Results. After 120 days of supplementation, the percentage of children with plasma zinc concentrations

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalPediatrics
Volume102
Issue number1 I
DOIs
StatePublished - 1998

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Preschool Children
Respiratory Tract Infections
Zinc
Incidence
Immunocompetence
Malnutrition
Randomized Controlled Trials
Morbidity
Mortality

Keywords

  • Experimental trial
  • Nutrition
  • Pneumonia
  • Respiratory infections
  • Zinc

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children : A double-blind, controlled trial. / Sazawal, S.; Black, Robert E; Jalla, S.; Mazumdar, S.; Sinha, A.; Bhan, M. K.

In: Pediatrics, Vol. 102, No. 1 I, 1998, p. 1-5.

Research output: Contribution to journalArticle

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