Zinc supplementation did not affect caloric or protein emake in presence of free availability of food

P. Dhinpa, S. Sazawal, R. E. Black, S. Jalla, S. Mazumder, M. Bentlev, M. K. Bhan

Research output: Contribution to journalArticlepeer-review


Meta-analysis of zinc supplementation trials has confirmed a growth effect in zinc deficient children. Improved appetite and intake are possible mechanisms for this effect. Within a zinc supplementation trial, we evaluated if zinc caused an improvement in appetite and there by an increase in intake from a standardised test meal. A subsample of 128 children (47 in zinc + vitamins group (Z), 42 in vitamins group (V), 39 in true placebo (P) were selected, matched for age and duration of followup. Each child was investigated by a direct observation of 6h, after a test meal consisting of 200g Nestum, 200ml milk, 20g puffed rice, 75g banana, SOg bread and 10 grapes was given to the mother. All intakes, including those from non test-meal foods were receded. Mothers' stimulations were also recorded. Groups were comparable for all assessed baseline features. Stimulation to eat from mother was also similar, (Physical help given (56) Z 47, V 46, P 43; Stimulated (%) Z 33, V31, P 29; Pressurised (%) Z 6, V 5, P 5). The median total ( Z 364, V 333, P 324), and test meal (Z 312, V 297, P 315) calories offered were similar. There were no significant differences in the caloric intake, total (Z 148, V146, 138) or from testmeal (Z 111, V130, P 92). The protein offered (Z 7, V 6, P 6) and consumed (Z 3 , V 3, P 2) was also similar. Subgroup analysis of stunted children, males and those with zinc level <60 ug/dl were similar to overall results. We conclude that zinc supplementation did not have effect on appetite of a magnitude so as to result in higher food intakes.

Original languageEnglish (US)
Pages (from-to)A480
JournalFASEB Journal
Issue number3
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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