Zinc, iron, copper and magnesium concentrations in tissues of rats fed various amounts of zinc

H. K. Kang, P. W. Harvey, J. L. Valentine, M. E. Swendseid

Research output: Contribution to journalArticle

Abstract

An experiment was conducted with rats to determine the effects on the tissue concentrations of Zn, Fe, Cu, and Mg of feeding various amounts of zinc. The rats were pair-fed one of the following diets for four weeks: Diet A, a zinc-deficient diet; a diet containing the recommended amount of zinc (diet A plus 55 μg of zinc per gram of diet), or diet A plus 550 μg zinc per gram of diet. Concentrations of these elements in various tissues were determined by atomic absorption spectrometry after wet digestion. Feeding the rats zinc-supplemented diets resulted in increased zinc in blood, heart, kidney, and liver, and a marked decrease of iron in kidney and liver. Concentrations of the other two elements were unchanged in all tissues. Thus, the effect of zinc in decreasing iron concentrations in liver, observed by several investigators when rats were fed toxic amounts of zinc, also occurs when zinc is administered in normal or subtoxic amounts.

Original languageEnglish (US)
Pages (from-to)1834-1837
Number of pages4
JournalClinical chemistry
Volume23
Issue number10
DOIs
StatePublished - 1977

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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