Zinc cream and reliability of tuberculosis skin testing

V. Bhargavi Rao; Tom F. Pelly; Robert H. Gilman; Lilia Cabrera; Jose Delgado; Giselle Soto; Jon S. Friedland; A. Roderick Escombe; Robert E. Black; Carlton A. Evans

doi:10.3201/eid1307.070227

Zinc cream and reliability of tuberculosis skin testing

V. Bhargavi Rao, Tom F. Pelly, Robert H. Gilman, Lilia Cabrera, Jose Delgado, Giselle Soto, Jon S. Friedland, A. Roderick Escombe, Robert E. Black, Carlton A. Evans

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

In 50 healthy Peruvian shantytown residents, zinc cream applied to tuberculosis skin-test sites caused a 32% increase in induration compared with placebo cream. Persons with lower plasma zinc had smaller skin-test reactions and greater augmentation with zinc cream. Zinc deficiency caused false-negative skin-test results, and topical zinc supplementation augmented antimycobacterial immune responses enough to improve diagnosis.

Original language	English (US)
Pages (from-to)	1101-1104
Number of pages	4
Journal	Emerging infectious diseases
Volume	13
Issue number	7
DOIs	https://doi.org/10.3201/eid1307.070227
State	Published - Jul 2007

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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abstract = "In 50 healthy Peruvian shantytown residents, zinc cream applied to tuberculosis skin-test sites caused a 32% increase in induration compared with placebo cream. Persons with lower plasma zinc had smaller skin-test reactions and greater augmentation with zinc cream. Zinc deficiency caused false-negative skin-test results, and topical zinc supplementation augmented antimycobacterial immune responses enough to improve diagnosis.",

author = "Rao, {V. Bhargavi} and Pelly, {Tom F.} and Gilman, {Robert H.} and Lilia Cabrera and Jose Delgado and Giselle Soto and Friedland, {Jon S.} and Escombe, {A. Roderick} and Black, {Robert E.} and Evans, {Carlton A.}",

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AU - Rao, V. Bhargavi

AU - Pelly, Tom F.

AU - Gilman, Robert H.

AU - Cabrera, Lilia

AU - Delgado, Jose

AU - Soto, Giselle

AU - Friedland, Jon S.

AU - Escombe, A. Roderick

AU - Black, Robert E.

AU - Evans, Carlton A.

PY - 2007/7

Y1 - 2007/7

N2 - In 50 healthy Peruvian shantytown residents, zinc cream applied to tuberculosis skin-test sites caused a 32% increase in induration compared with placebo cream. Persons with lower plasma zinc had smaller skin-test reactions and greater augmentation with zinc cream. Zinc deficiency caused false-negative skin-test results, and topical zinc supplementation augmented antimycobacterial immune responses enough to improve diagnosis.

AB - In 50 healthy Peruvian shantytown residents, zinc cream applied to tuberculosis skin-test sites caused a 32% increase in induration compared with placebo cream. Persons with lower plasma zinc had smaller skin-test reactions and greater augmentation with zinc cream. Zinc deficiency caused false-negative skin-test results, and topical zinc supplementation augmented antimycobacterial immune responses enough to improve diagnosis.

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Zinc cream and reliability of tuberculosis skin testing

Abstract

ASJC Scopus subject areas

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