Zika virus directly infects peripheral neurons and induces cell death

Yohan Oh, Feiran Zhang, Yaqing Wang, Emily M. Lee, In Young Choi, Hotae Lim, Fahimeh Mirakhori, Ronghua Li, Luoxiu Huang, Tianlei Xu, Hao Wu, Cui Li, Cheng Feng Qin, Zhexing Wen, Qing Feng Wu, Hengli Tang, Zhiheng Xu, Peng Jin, Hongjun Song, Guo Li MingGabsang Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Zika virus (ZIKV) infection is associated with neurological disorders of both the CNS and peripheral nervous systems (PNS), yet few studies have directly examined PNS infection. Here we show that intraperitoneally or intraventricularly injected ZIKV in the mouse can infect and impact peripheral neurons in vivo. Moreover, ZIKV productively infects stem-cell-derived human neural crest cells and peripheral neurons in vitro, leading to increased cell death, transcriptional dysregulation and cell-type-specific molecular pathology.

Original languageEnglish (US)
Pages (from-to)1209-1212
Number of pages4
JournalNature neuroscience
Volume20
Issue number9
DOIs
StatePublished - Sep 1 2017

ASJC Scopus subject areas

  • Neuroscience(all)

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