@article{ec5a93c672e14ff0b79e7ecfe1b53ee1,
title = "Zika virus directly infects peripheral neurons and induces cell death",
abstract = "Zika virus (ZIKV) infection is associated with neurological disorders of both the CNS and peripheral nervous systems (PNS), yet few studies have directly examined PNS infection. Here we show that intraperitoneally or intraventricularly injected ZIKV in the mouse can infect and impact peripheral neurons in vivo. Moreover, ZIKV productively infects stem-cell-derived human neural crest cells and peripheral neurons in vitro, leading to increased cell death, transcriptional dysregulation and cell-type-specific molecular pathology.",
author = "Yohan Oh and Feiran Zhang and Yaqing Wang and Lee, {Emily M.} and Choi, {In Young} and Hotae Lim and Fahimeh Mirakhori and Ronghua Li and Luoxiu Huang and Tianlei Xu and Hao Wu and Cui Li and Qin, {Cheng Feng} and Zhexing Wen and Wu, {Qing Feng} and Hengli Tang and Zhiheng Xu and Peng Jin and Hongjun Song and Ming, {Guo Li} and Gabsang Lee",
note = "Funding Information: We thank K.M. Christian for comments. We acknowledge the services of H. Zhang at Flow Cytometry Core Facility (JHSPH), W. Tang at Omega Bioservices (Omega Bio-tek, Inc.), and M. Zwick and B. Isett at the Emory Integrated Genomics Core (EIGC). This work was supported by grants from the Robertson Investigator Award from New York Stem Cell Foundation (G.L.), Maryland Stem Cell Research Funding (MSCRF; G.L., H.S. and G.-l.M.), NIH R01NS093213 (G.L.), R01MH105128 and R35NS097370 (G.-l.M.), U19AI131130 (G.-l.M., Z.W., H.T. and P.J.), U19MH106434, P01NS097206 and R37NS047344 (H.S.), R21AI119530 (H.T.), National Natural Science Foundation of China (31430037), Innovation Program of the Chinese Academy of Sciences (QYZDJ-SSW-SMC007), Shanghai Brain-Intelligence Project from STCSM (16JC1420500), Beijing Brain Project (Z161100002616004) to Z.X. and Y.W., FSU Zika seed funding (H.T.), and the Adelson Medical Research Foundation (G.-l.M.). The authors (G.L., Y.O., G.-l.M. and H.S.) acknowledge the joint participation of the Adrienne Helis Malvin Medical Research Foundation.",
year = "2017",
month = sep,
day = "1",
doi = "10.1038/nn.4612",
language = "English (US)",
volume = "20",
pages = "1209--1212",
journal = "Nature neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "9",
}