Abstract
Despite the general decrease in overall incidence of colorectal cancer since the early 1990s, the incidence of colorectal cancer in patients less than 50 years old has nearly doubled. A systematic review was performed using the PubMed database (2011-2020) and Cochrane Database of Systematic Reviews (2011-2021) to identify studies (published in English) evaluating epidemiologic, clinical, hereditary, and molecular features; as well as evaluation, management, and prognosis of youngonset colorectal cancer patients. Our search yielded a total of 3401 articles, after applying our inclusion criteria. We fully reviewed 94 full-length studies. This systematic review demonstrates the increasing incidence of young-onset colorectal cancer and highlights the importance of being hypervigilant for the differential diagnosis colorectal cancer when evaluating a young adult who presents with gastrointestinal symptoms.
Original language | English (US) |
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Pages (from-to) | 856-866 |
Number of pages | 11 |
Journal | World Journal of Gastrointestinal Oncology |
Volume | 13 |
Issue number | 8 |
DOIs | |
State | Published - 2021 |
Keywords
- Colorectal cancer
- Early-onset colorectal cancer
- Genetic
- Hereditary
- Young adult
- Young-onset colorectal cancer
ASJC Scopus subject areas
- Oncology
- Gastroenterology