Young-Onset Colorectal Cancer: A Review

Joy Zhou Done, Sandy H. Fang

Research output: Contribution to journalArticlepeer-review

Abstract

Despite the general decrease in overall incidence of colorectal cancer since the early 1990s, the incidence of colorectal cancer in patients less than 50 years old has nearly doubled. A systematic review was performed using the PubMed database (2011-2020) and Cochrane Database of Systematic Reviews (2011-2021) to identify studies (published in English) evaluating epidemiologic, clinical, hereditary, and molecular features; as well as evaluation, management, and prognosis of youngonset colorectal cancer patients. Our search yielded a total of 3401 articles, after applying our inclusion criteria. We fully reviewed 94 full-length studies. This systematic review demonstrates the increasing incidence of young-onset colorectal cancer and highlights the importance of being hypervigilant for the differential diagnosis colorectal cancer when evaluating a young adult who presents with gastrointestinal symptoms.

Original languageEnglish (US)
Pages (from-to)856-866
Number of pages11
JournalWorld Journal of Gastrointestinal Oncology
Volume13
Issue number8
DOIs
StatePublished - 2021

Keywords

  • Colorectal cancer
  • Early-onset colorectal cancer
  • Genetic
  • Hereditary
  • Young adult
  • Young-onset colorectal cancer

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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