Young infants can develop protective levels of neutralizing antibody after infection with respiratory syncytial virus

Joshua J. Shinoff; Katherine L. O'Brien; Bhagvanji Thumar; Jana B. Shaw; Raymond Reid; Wei Hua; Mathuram Santosham; Ruth A. Karron

doi:10.1086/591460

Young infants can develop protective levels of neutralizing antibody after infection with respiratory syncytial virus

Joshua J. Shinoff, Katherine L. O'Brien, Bhagvanji Thumar, Jana B. Shaw, Raymond Reid, Wei Hua, Mathuram Santosham, Ruth A. Karron

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Humoral immunity protects against severe respiratory syncytial virus (RSV) disease, but the range and magnitude of antibody responses in RSV-naive children after RSV infection have not been completely defined. We evaluated RSV-neutralizing antibody and immunoglobulin G responses to RSV F and G glycoproteins in 65 RSV-naive Navajo and White Mountain Apache children aged 0-24 months who were hospitalized with RSV infection. In these children, antibody responses developed against RSV F and G and the central conserved region of RSV G. Twenty-seven of 41 infants <6 months old developed reciprocal log₂ RSV neutralizing antibody titers ≥8.0, which correlate with protection of the lower respiratory tract. Multivariate analysis demonstrated that the level of preexisting neutralizing antibody at infection, not age, was the most important factor influencing this response. RSV can induce substantial neutralizing antibody responses in young infants when the titer of preexisting antibodies is low.

Original language	English (US)
Pages (from-to)	1007-1015
Number of pages	9
Journal	Journal of Infectious Diseases
Volume	198
Issue number	7
DOIs	https://doi.org/10.1086/591460
State	Published - Oct 1 2008

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1086/591460

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title = "Young infants can develop protective levels of neutralizing antibody after infection with respiratory syncytial virus",

abstract = "Humoral immunity protects against severe respiratory syncytial virus (RSV) disease, but the range and magnitude of antibody responses in RSV-naive children after RSV infection have not been completely defined. We evaluated RSV-neutralizing antibody and immunoglobulin G responses to RSV F and G glycoproteins in 65 RSV-naive Navajo and White Mountain Apache children aged 0-24 months who were hospitalized with RSV infection. In these children, antibody responses developed against RSV F and G and the central conserved region of RSV G. Twenty-seven of 41 infants <6 months old developed reciprocal log2 RSV neutralizing antibody titers ≥8.0, which correlate with protection of the lower respiratory tract. Multivariate analysis demonstrated that the level of preexisting neutralizing antibody at infection, not age, was the most important factor influencing this response. RSV can induce substantial neutralizing antibody responses in young infants when the titer of preexisting antibodies is low.",

author = "Shinoff, {Joshua J.} and O'Brien, {Katherine L.} and Bhagvanji Thumar and Shaw, {Jana B.} and Raymond Reid and Wei Hua and Mathuram Santosham and Karron, {Ruth A.}",

note = "Funding Information: Potential conflicts of interest: Some of the authors have received research grant or contract support from the National Institutes of Health (R.A.K. and K.L.O.), Wyeth Vaccines (R.A.K., K.L.O., and M.S.), or MedImmune (R.A.K., K.L.O., and M.S.); have served on scientific advisory boards for MedImmune (R.A.K.) and Wyeth Vaccines (K.L.O. and M.S.); or have received honoraria from Wyeth Vaccines (K.L.O. and M.S.). All other authors report no potential conflicts. Financial support: Wyeth Vaccines Research, Pearl River, New York.",

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AU - Hua, Wei

AU - Santosham, Mathuram

AU - Karron, Ruth A.

N1 - Funding Information: Potential conflicts of interest: Some of the authors have received research grant or contract support from the National Institutes of Health (R.A.K. and K.L.O.), Wyeth Vaccines (R.A.K., K.L.O., and M.S.), or MedImmune (R.A.K., K.L.O., and M.S.); have served on scientific advisory boards for MedImmune (R.A.K.) and Wyeth Vaccines (K.L.O. and M.S.); or have received honoraria from Wyeth Vaccines (K.L.O. and M.S.). All other authors report no potential conflicts. Financial support: Wyeth Vaccines Research, Pearl River, New York.

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N2 - Humoral immunity protects against severe respiratory syncytial virus (RSV) disease, but the range and magnitude of antibody responses in RSV-naive children after RSV infection have not been completely defined. We evaluated RSV-neutralizing antibody and immunoglobulin G responses to RSV F and G glycoproteins in 65 RSV-naive Navajo and White Mountain Apache children aged 0-24 months who were hospitalized with RSV infection. In these children, antibody responses developed against RSV F and G and the central conserved region of RSV G. Twenty-seven of 41 infants <6 months old developed reciprocal log2 RSV neutralizing antibody titers ≥8.0, which correlate with protection of the lower respiratory tract. Multivariate analysis demonstrated that the level of preexisting neutralizing antibody at infection, not age, was the most important factor influencing this response. RSV can induce substantial neutralizing antibody responses in young infants when the titer of preexisting antibodies is low.

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Young infants can develop protective levels of neutralizing antibody after infection with respiratory syncytial virus

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