Young and old Pavlovian fear memories can be modified with extinction training during

Elisa C K Steinfurth, Jonathan W. Kanen, Candace M. Raio, Roger L. Clem, Richard L Huganir, Elizabeth A. Phelps

Research output: Contribution to journalArticle

Abstract

Extinction training during reconsolidation has been shown to persistently diminish conditioned fear responses across species. We investigated in humans if older fear memories can benefit similarly. Using a Pavlovian fear conditioning paradigm we compared standard extinction and extinction after memory reactivation 1 d or 7 d following acquisition. Participants who underwent extinction during reconsolidation showed no evidence of fear recovery, whereas fear responses returned in participants who underwent standard extinction. We observed this effect in young and old fear memories. Extending the beneficial use of reconsolidation to older fear memories in humans is promising for therapeutic applications.

Original languageEnglish (US)
Pages (from-to)338-341
Number of pages4
JournalLearning and Memory
Volume21
Issue number7
DOIs
StatePublished - 2014

Fingerprint

Fear
Psychological Extinction

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Steinfurth, E. C. K., Kanen, J. W., Raio, C. M., Clem, R. L., Huganir, R. L., & Phelps, E. A. (2014). Young and old Pavlovian fear memories can be modified with extinction training during. Learning and Memory, 21(7), 338-341. https://doi.org/10.1101/lm.033589.113

Young and old Pavlovian fear memories can be modified with extinction training during. / Steinfurth, Elisa C K; Kanen, Jonathan W.; Raio, Candace M.; Clem, Roger L.; Huganir, Richard L; Phelps, Elizabeth A.

In: Learning and Memory, Vol. 21, No. 7, 2014, p. 338-341.

Research output: Contribution to journalArticle

Steinfurth, Elisa C K ; Kanen, Jonathan W. ; Raio, Candace M. ; Clem, Roger L. ; Huganir, Richard L ; Phelps, Elizabeth A. / Young and old Pavlovian fear memories can be modified with extinction training during. In: Learning and Memory. 2014 ; Vol. 21, No. 7. pp. 338-341.
@article{889d23569e3e41388b4f1991f2e5340a,
title = "Young and old Pavlovian fear memories can be modified with extinction training during",
abstract = "Extinction training during reconsolidation has been shown to persistently diminish conditioned fear responses across species. We investigated in humans if older fear memories can benefit similarly. Using a Pavlovian fear conditioning paradigm we compared standard extinction and extinction after memory reactivation 1 d or 7 d following acquisition. Participants who underwent extinction during reconsolidation showed no evidence of fear recovery, whereas fear responses returned in participants who underwent standard extinction. We observed this effect in young and old fear memories. Extending the beneficial use of reconsolidation to older fear memories in humans is promising for therapeutic applications.",
author = "Steinfurth, {Elisa C K} and Kanen, {Jonathan W.} and Raio, {Candace M.} and Clem, {Roger L.} and Huganir, {Richard L} and Phelps, {Elizabeth A.}",
year = "2014",
doi = "10.1101/lm.033589.113",
language = "English (US)",
volume = "21",
pages = "338--341",
journal = "Learning and Memory",
issn = "1072-0502",
publisher = "Cold Spring Harbor Laboratory Press",
number = "7",

}

TY - JOUR

T1 - Young and old Pavlovian fear memories can be modified with extinction training during

AU - Steinfurth, Elisa C K

AU - Kanen, Jonathan W.

AU - Raio, Candace M.

AU - Clem, Roger L.

AU - Huganir, Richard L

AU - Phelps, Elizabeth A.

PY - 2014

Y1 - 2014

N2 - Extinction training during reconsolidation has been shown to persistently diminish conditioned fear responses across species. We investigated in humans if older fear memories can benefit similarly. Using a Pavlovian fear conditioning paradigm we compared standard extinction and extinction after memory reactivation 1 d or 7 d following acquisition. Participants who underwent extinction during reconsolidation showed no evidence of fear recovery, whereas fear responses returned in participants who underwent standard extinction. We observed this effect in young and old fear memories. Extending the beneficial use of reconsolidation to older fear memories in humans is promising for therapeutic applications.

AB - Extinction training during reconsolidation has been shown to persistently diminish conditioned fear responses across species. We investigated in humans if older fear memories can benefit similarly. Using a Pavlovian fear conditioning paradigm we compared standard extinction and extinction after memory reactivation 1 d or 7 d following acquisition. Participants who underwent extinction during reconsolidation showed no evidence of fear recovery, whereas fear responses returned in participants who underwent standard extinction. We observed this effect in young and old fear memories. Extending the beneficial use of reconsolidation to older fear memories in humans is promising for therapeutic applications.

UR - http://www.scopus.com/inward/record.url?scp=84904548331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904548331&partnerID=8YFLogxK

U2 - 10.1101/lm.033589.113

DO - 10.1101/lm.033589.113

M3 - Article

VL - 21

SP - 338

EP - 341

JO - Learning and Memory

JF - Learning and Memory

SN - 1072-0502

IS - 7

ER -