Yes-associated protein in the liver: Regulation of hepatic development, repair, cell fate determination and tumorigenesis

Quy Nguyen, Robert A. Anders, Gianfranco Alpini, Haibo Bai

Research output: Contribution to journalReview article

Abstract

The liver is a vital organ that plays a major role in many bodily functions from protein production and blood clotting to cholesterol, glucose and iron metabolism and nutrition storage. Maintenance of liver homeostasis is critical for these essential bodily functions and disruption of liver homeostasis causes various kinds of liver diseases, some of which have high mortality rate. Recent research advances of the Hippo signalling pathway have revealed its nuclear effector, Yes-associated protein, as an important regulator of liver development, repair, cell fate determination and tumorigenesis. Therefore, a precise control of Yes-associated protein activity is critical for the maintenance of liver homeostasis. This review is going to summarize the discoveries on how the manipulation of Yes-associated protein activity affects liver homeostasis and induces liver diseases and the regulatory mechanisms that determine the Yes-associated protein activity in the liver. Finally, we will discuss the potential of targeting Yes-associated protein as therapeutic strategies in liver diseases.

Original languageEnglish (US)
Pages (from-to)826-835
Number of pages10
JournalDigestive and Liver Disease
Volume47
Issue number10
DOIs
StatePublished - Oct 1 2015

Keywords

  • Hippo signalling pathway
  • Liver
  • YAP

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Yes-associated protein in the liver: Regulation of hepatic development, repair, cell fate determination and tumorigenesis'. Together they form a unique fingerprint.

  • Cite this