TY - JOUR
T1 - Yes-associated protein in the liver
T2 - Regulation of hepatic development, repair, cell fate determination and tumorigenesis
AU - Nguyen, Quy
AU - Anders, Robert A.
AU - Alpini, Gianfranco
AU - Bai, Haibo
N1 - Funding Information:
Portion of this work was supported by the Dr. Nicholas C. Hightower Centennial Chair of Gastroenterology from Scott & White, a VA Research Career Scientist Award, a VA Merit award and NIH R01DK076898 grant to Dr. G. Alpini, and a grant award from BaylorScott&White operational funds to H. Bai. This work is also supported by R01DK080736 to R. Anders.
Publisher Copyright:
© 2015.Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - The liver is a vital organ that plays a major role in many bodily functions from protein production and blood clotting to cholesterol, glucose and iron metabolism and nutrition storage. Maintenance of liver homeostasis is critical for these essential bodily functions and disruption of liver homeostasis causes various kinds of liver diseases, some of which have high mortality rate. Recent research advances of the Hippo signalling pathway have revealed its nuclear effector, Yes-associated protein, as an important regulator of liver development, repair, cell fate determination and tumorigenesis. Therefore, a precise control of Yes-associated protein activity is critical for the maintenance of liver homeostasis. This review is going to summarize the discoveries on how the manipulation of Yes-associated protein activity affects liver homeostasis and induces liver diseases and the regulatory mechanisms that determine the Yes-associated protein activity in the liver. Finally, we will discuss the potential of targeting Yes-associated protein as therapeutic strategies in liver diseases.
AB - The liver is a vital organ that plays a major role in many bodily functions from protein production and blood clotting to cholesterol, glucose and iron metabolism and nutrition storage. Maintenance of liver homeostasis is critical for these essential bodily functions and disruption of liver homeostasis causes various kinds of liver diseases, some of which have high mortality rate. Recent research advances of the Hippo signalling pathway have revealed its nuclear effector, Yes-associated protein, as an important regulator of liver development, repair, cell fate determination and tumorigenesis. Therefore, a precise control of Yes-associated protein activity is critical for the maintenance of liver homeostasis. This review is going to summarize the discoveries on how the manipulation of Yes-associated protein activity affects liver homeostasis and induces liver diseases and the regulatory mechanisms that determine the Yes-associated protein activity in the liver. Finally, we will discuss the potential of targeting Yes-associated protein as therapeutic strategies in liver diseases.
KW - Hippo signalling pathway
KW - Liver
KW - YAP
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U2 - 10.1016/j.dld.2015.05.011
DO - 10.1016/j.dld.2015.05.011
M3 - Review article
C2 - 26093945
AN - SCOPUS:84942194781
SN - 1590-8658
VL - 47
SP - 826
EP - 835
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 10
ER -