Yes-associated protein 1 regulates the stability of δNp63α

Aditi Chatterjee, Tanusree Sen, Xiaofei Chang, David Sidransky

Research output: Contribution to journalArticlepeer-review

Abstract

Regulation of δNp63α can be achieved at the transcriptional and post-translational levels, with the latter being greatly influenced by external stimuli such as DNA damaging agents. In this present study, we demonstrated that δNp63α physical interacts with Yes-associated protein 1 (Yap1). Ectopic expression of Yap1 decreased the stability and the half-like of δNp63α and resulted in ubiquitin-dependent degradation of δNp63α. Further, the cisplatin mediated degradation of δNp63α is attenuated with the downregulation of Yap1. Thus, our results strongly suggest that Yap1 plays a role in the regulation of endogenous δNp63α levels and is likely to contribute to the regulation of δNp63α, in physiological conditions.

Original languageEnglish (US)
Pages (from-to)162-167
Number of pages6
JournalCell Cycle
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Cisplatin
  • Protein stability
  • Ubiquitination
  • Yap1
  • δNp63α

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Yes-associated protein 1 regulates the stability of δNp63α'. Together they form a unique fingerprint.

Cite this