YAC transgenics and the study of genetics and human disease

Bruce T. Lamb; John D. Gearhart

doi:10.1016/0959-437X(95)80049-2

YAC transgenics and the study of genetics and human disease

Bruce T. Lamb, John D. Gearhart

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Advances in yeast artificial chromosome (YAC) technologies over the past decade have enabled the precise identification and manipulation of large genomic regions (>100 kb) of DNA. Introduction of YACs into the mouse germline has now been accomplished through transfection of mouse embryonic stem cells as well as through pronuclear microinjection, allowing the efficient transfer of defined genomic loci into mice. YAC transgenics will have a profound impact on the development of transgenic mice as bioreactors and as models of human disease, and on the functional analysis of higher order genomic structure.

Original language	English (US)
Pages (from-to)	342-348
Number of pages	7
Journal	Current Opinion in Genetics and Development
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/0959-437X(95)80049-2
State	Published - 1995

ASJC Scopus subject areas

Developmental Biology
Genetics

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AB - Advances in yeast artificial chromosome (YAC) technologies over the past decade have enabled the precise identification and manipulation of large genomic regions (>100 kb) of DNA. Introduction of YACs into the mouse germline has now been accomplished through transfection of mouse embryonic stem cells as well as through pronuclear microinjection, allowing the efficient transfer of defined genomic loci into mice. YAC transgenics will have a profound impact on the development of transgenic mice as bioreactors and as models of human disease, and on the functional analysis of higher order genomic structure.

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