Y chromosome binary markers to study the high prevalence of males in Sardinian centenarians and the genetic structure of the Sardinian population

Giuseppe Passarino, Peter A. Underhill, L. Luca Cavalli-Sforza, Ornella Semino, Giovanni M. Pes, Ciriaco Carru, Luigi Ferrucci, Massimiliano Bonafè, Claudio Franceschi, Luca Deiana, Giovannella Baggio, Giovanna De Benedictis

Research output: Contribution to journalArticle

Abstract

We have analyzed a sample of 40 centenarians and 116 young controls from Sardinia, with a set of new Y chromosome binary markers, to evaluate if Y chromosome genes are involved in the high prevalence of males among centenarian Sardinians (1/2 vs. 1/4 in other populations studied). The results indicate that none of the seven lineages that account for >97% of the Y chromosome diversity in Sardinia provide an advantage with respect to the extreme longevity. However, our results, although based on the male-specific Y chromosome polymorphisms, give a clear profile of the pattern of genetic variability in Sardinia. Indeed they indicate that the Sardinian population had two main founder populations that have evolved in isolation for at least the last 5,000 years. These findings set the stage for future studies on longevity and other complex traits in Sardinia.

Original languageEnglish (US)
Pages (from-to)136-139
Number of pages4
JournalHuman Heredity
Volume52
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

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Keywords

  • Centenarians
  • Isolated population
  • Longevity
  • Sardinia
  • Y chromosome

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Passarino, G., Underhill, P. A., Cavalli-Sforza, L. L., Semino, O., Pes, G. M., Carru, C., Ferrucci, L., Bonafè, M., Franceschi, C., Deiana, L., Baggio, G., & De Benedictis, G. (2001). Y chromosome binary markers to study the high prevalence of males in Sardinian centenarians and the genetic structure of the Sardinian population. Human Heredity, 52(3), 136-139. https://doi.org/10.1159/000053368