XRN1: A Major 5' to 3' Exoribonuclease in Eukaryotic Cells

Sarah Geisler; Jeff Coller

doi:10.1016/B978-0-12-404740-2.00005-7

XRN1: A Major 5' to 3' Exoribonuclease in Eukaryotic Cells

Sarah Geisler, Jeff Coller

Research output: Chapter in Book/Report/Conference proceeding › Chapter

8 Scopus citations

Abstract

The degradation of RNA is a critical aspect of gene regulation. Correspondingly, ribonucleases exist within the cell to degrade RNA in specific cellular contexts. An important and conserved ribonuclease is called XRN1. This enzyme, an exoribonuclease, degrades RNA in a processive 5' to 3' direction. Substrates for XRN1 include decapped mRNA, endonucleolytically cleaved mRNA, lncRNA, and some aberrant tRNAs. In addition, XRN1 serves a vital role in the processing and maturation of the 5' ends of rRNA and snoRNAs. In this review, we discuss some of the important roles of XRN1 in the cell.

Original language	English (US)
Title of host publication	Enzymes
Publisher	Academic Press
Pages	97-114
Number of pages	18
DOIs	https://doi.org/10.1016/B978-0-12-404740-2.00005-7
State	Published - 2012
Externally published	Yes

Publication series

Name	Enzymes
Volume	31
ISSN (Print)	1874-6047

Keywords

RNA degradation
RNA stability
RNA turnover
Ribonuclease
XRN1

ASJC Scopus subject areas

Biotechnology
Biophysics
Biochemistry
Molecular Biology

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10.1016/B978-0-12-404740-2.00005-7

Cite this

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title = "XRN1: A Major 5' to 3' Exoribonuclease in Eukaryotic Cells",

abstract = "The degradation of RNA is a critical aspect of gene regulation. Correspondingly, ribonucleases exist within the cell to degrade RNA in specific cellular contexts. An important and conserved ribonuclease is called XRN1. This enzyme, an exoribonuclease, degrades RNA in a processive 5' to 3' direction. Substrates for XRN1 include decapped mRNA, endonucleolytically cleaved mRNA, lncRNA, and some aberrant tRNAs. In addition, XRN1 serves a vital role in the processing and maturation of the 5' ends of rRNA and snoRNAs. In this review, we discuss some of the important roles of XRN1 in the cell.",

keywords = "RNA degradation, RNA stability, RNA turnover, Ribonuclease, XRN1",

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language = "English (US)",

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AU - Coller, Jeff

PY - 2012

Y1 - 2012

N2 - The degradation of RNA is a critical aspect of gene regulation. Correspondingly, ribonucleases exist within the cell to degrade RNA in specific cellular contexts. An important and conserved ribonuclease is called XRN1. This enzyme, an exoribonuclease, degrades RNA in a processive 5' to 3' direction. Substrates for XRN1 include decapped mRNA, endonucleolytically cleaved mRNA, lncRNA, and some aberrant tRNAs. In addition, XRN1 serves a vital role in the processing and maturation of the 5' ends of rRNA and snoRNAs. In this review, we discuss some of the important roles of XRN1 in the cell.

AB - The degradation of RNA is a critical aspect of gene regulation. Correspondingly, ribonucleases exist within the cell to degrade RNA in specific cellular contexts. An important and conserved ribonuclease is called XRN1. This enzyme, an exoribonuclease, degrades RNA in a processive 5' to 3' direction. Substrates for XRN1 include decapped mRNA, endonucleolytically cleaved mRNA, lncRNA, and some aberrant tRNAs. In addition, XRN1 serves a vital role in the processing and maturation of the 5' ends of rRNA and snoRNAs. In this review, we discuss some of the important roles of XRN1 in the cell.

KW - RNA degradation

KW - RNA stability

KW - RNA turnover

KW - Ribonuclease

KW - XRN1

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DO - 10.1016/B978-0-12-404740-2.00005-7

M3 - Chapter

AN - SCOPUS:84866890839

T3 - Enzymes

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BT - Enzymes

PB - Academic Press

ER -

XRN1: A Major 5' to 3' Exoribonuclease in Eukaryotic Cells

Abstract

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Keywords

ASJC Scopus subject areas

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