Abstract
Contributions of dietary miRNAs to circulating small RNA profiles would have profound implications for interpretation of miRNA biomarker studies: presumptive disease-specific markers might instead indicate responses to disease-associated quantitative or qualitative dietary alteration. This examination weighs the evidence for a 2-fold hypothesis: first, that ingested biological matter contributes directly to the miRNA complement of body compartments; and second, that these diet-derived exogenous miRNAs (or "xenomiRs") affect total miRNA profiles as part of a circulating miRNA homeostasis that is altered in many diseases. Homeostasis of highdensity lipoprotein (HDL), a known miRNA carrier-provides a model as a proposed component of broader miRNA homeostasis. Further research into the dietary xenomiR hypothesis is needed to ensure rigor in the search for truly disease-specific miRNA biomarkers.
Original language | English (US) |
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Pages (from-to) | 1147-1154 |
Number of pages | 8 |
Journal | RNA Biology |
Volume | 9 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2012 |
Keywords
- Biomarker
- Cancer
- Cholesterol
- Diet
- HDL
- Homeostasis
- LDL
- Nutrition
- XenomiR
- microRNA
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology