Xanthine oxidoreductase in respiratory and cardiovascular disorders

Research output: Contribution to journalReview articlepeer-review

Abstract

In addition to its critical role in purine metabolism, xanthine oxidoreductase (XOR) has been implicated in the development of tissue oxidative damage in a wide variety of respiratory and cardiovascular disorders such as acute lung injury, ischemia-reperfusion injury, atherosclerosis, heart failure, and arterial hypertension. Although much remains to be clarified about the regulation and signaling pathways of this enzyme, it is quite evident from abundant investigation in animal models and some human trials that XOR inhibition can favorably alter critical disease processes and impact outcomes. From promising bench-to-bedside data, a better understanding of this enigmatic enzyme is emerging. However, the positive findings related to XOR inhibition need to be confirmed in large-scale, well-designed clinical trials. This will hopefully provide new opportunities for therapeutic intervention. This article reviews the available evidence involving XOR in oxidative states with specific emphasis on respiratory and cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)L830-L840
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume294
Issue number5
DOIs
StatePublished - May 2008

Keywords

  • Cardiovascular diseases
  • Oxidative stress
  • Reactive oxygen species
  • Respiratory diseases
  • Xanthine dehydrogenase
  • Xanthine oxidase

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology

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