XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma

X. F. Liu, Lee J. Helman, C. Yeung, T. K. Bera, B. Lee, I. Pastan

Research output: Contribution to journalArticle

Abstract

Our previous expressed sequence tag database analysis indicates that XAGE-1 is frequently found in Ewing's sarcoma and alveolar rhabdomyosarcoma (U. Brinkmann et al., Cancer Res., 59: 1445-1448, 1999). Using Northern blots and RNA dot blots, we have now found that XAGE-1 is highly expressed in normal testis, in seven of eight Ewing's cell lines, in four of nine Ewing's sarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample. The gene is located on the X chromosome. The full-length cDNA contains 611 bp and predicts a protein of M(r) 16,300 with a potential transmembrane domain at the NH2 terminus. XAGE-1 shares homology with GAGE/PAGE proteins in the COOH-terminal end. These findings could be valuable for cancer diagnosis and cancer immunotherapy.

Original languageEnglish (US)
Pages (from-to)4752-4755
Number of pages4
JournalCancer Research
Volume60
Issue number17
StatePublished - Sep 1 2000
Externally publishedYes

Fingerprint

Ewing's Sarcoma
Alveolar Rhabdomyosarcoma
Genes
Neoplasms
Expressed Sequence Tags
X Chromosome
Northern Blotting
Membrane Potentials
Immunotherapy
Testis
Proteins
Complementary DNA
Databases
RNA
Cell Line

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Liu, X. F., Helman, L. J., Yeung, C., Bera, T. K., Lee, B., & Pastan, I. (2000). XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. Cancer Research, 60(17), 4752-4755.

XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. / Liu, X. F.; Helman, Lee J.; Yeung, C.; Bera, T. K.; Lee, B.; Pastan, I.

In: Cancer Research, Vol. 60, No. 17, 01.09.2000, p. 4752-4755.

Research output: Contribution to journalArticle

Liu, XF, Helman, LJ, Yeung, C, Bera, TK, Lee, B & Pastan, I 2000, 'XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma', Cancer Research, vol. 60, no. 17, pp. 4752-4755.
Liu XF, Helman LJ, Yeung C, Bera TK, Lee B, Pastan I. XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. Cancer Research. 2000 Sep 1;60(17):4752-4755.
Liu, X. F. ; Helman, Lee J. ; Yeung, C. ; Bera, T. K. ; Lee, B. ; Pastan, I. / XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. In: Cancer Research. 2000 ; Vol. 60, No. 17. pp. 4752-4755.
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