XA new DUB makes linear ubiquitin a party to its own destruction

Reuven Wiener, Cynthia Wolberger

Research output: Contribution to journalShort surveypeer-review

Abstract

Linear ubiquitin (Ub) plays a role in nuclear factor κB signaling, but the deubiquitinating enzyme that disassembles these chains was unknown. In this issue of Cell, Keusekotten et al. identify a new enzyme that disassembles linear chains with the use of a mechanism that relies on Ub itself to help catalyze peptide bond cleavage.

Original languageEnglish (US)
Number of pages1
JournalCell
Volume153
Issue number6
DOIs
StatePublished - Jun 6 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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