XA new DUB makes linear ubiquitin a party to its own destruction

Reuven Wiener; Cynthia Wolberger

doi:10.1016/j.cell.2013.05.018

XA new DUB makes linear ubiquitin a party to its own destruction

Reuven Wiener, Cynthia Wolberger

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

Abstract

Linear ubiquitin (Ub) plays a role in nuclear factor κB signaling, but the deubiquitinating enzyme that disassembles these chains was unknown. In this issue of Cell, Keusekotten et al. identify a new enzyme that disassembles linear chains with the use of a mechanism that relies on Ub itself to help catalyze peptide bond cleavage.

Original language	English (US)
Pages (from-to)	1189
Number of pages	1
Journal	Cell
Volume	153
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2013.05.018
State	Published - Jun 6 2013

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2013.05.018

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title = "XA new DUB makes linear ubiquitin a party to its own destruction",

abstract = "Linear ubiquitin (Ub) plays a role in nuclear factor κB signaling, but the deubiquitinating enzyme that disassembles these chains was unknown. In this issue of Cell, Keusekotten et al. identify a new enzyme that disassembles linear chains with the use of a mechanism that relies on Ub itself to help catalyze peptide bond cleavage.",

author = "Reuven Wiener and Cynthia Wolberger",

year = "2013",

month = jun,

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doi = "10.1016/j.cell.2013.05.018",

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journal = "Cell",

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T1 - XA new DUB makes linear ubiquitin a party to its own destruction

AU - Wiener, Reuven

AU - Wolberger, Cynthia

PY - 2013/6/6

Y1 - 2013/6/6

N2 - Linear ubiquitin (Ub) plays a role in nuclear factor κB signaling, but the deubiquitinating enzyme that disassembles these chains was unknown. In this issue of Cell, Keusekotten et al. identify a new enzyme that disassembles linear chains with the use of a mechanism that relies on Ub itself to help catalyze peptide bond cleavage.

AB - Linear ubiquitin (Ub) plays a role in nuclear factor κB signaling, but the deubiquitinating enzyme that disassembles these chains was unknown. In this issue of Cell, Keusekotten et al. identify a new enzyme that disassembles linear chains with the use of a mechanism that relies on Ub itself to help catalyze peptide bond cleavage.

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DO - 10.1016/j.cell.2013.05.018

M3 - Short survey

C2 - 23746836

AN - SCOPUS:84878863491

SN - 0092-8674

VL - 153

SP - 1189

JO - Cell

JF - Cell

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XA new DUB makes linear ubiquitin a party to its own destruction

Abstract

ASJC Scopus subject areas

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