X-ray microbeams: Tumor therapy and central nervous system research

F. A. Dilmanian; Y. Qu; S. Liu; C. D. Cool; J. Gilbert; J. F. Hainfeld; C. A. Kruse; J. Laterra; D. Lenihan; M. M. Nawrocky; G. Pappas; C. I. Sze; T. Yuasa; N. Zhong; Z. Zhong; J. W. McDonald

doi:10.1016/j.nima.2005.03.062

X-ray microbeams: Tumor therapy and central nervous system research

F. A. Dilmanian, Y. Qu, S. Liu, C. D. Cool, J. Gilbert, J. F. Hainfeld, C. A. Kruse, J. Laterra, D. Lenihan, M. M. Nawrocky, G. Pappas, C. I. Sze, T. Yuasa, N. Zhong, Z. Zhong, J. W. McDonald

School of Medicine

Research output: Contribution to journal › Conference article › peer-review

51 Scopus citations

Abstract

Irradiation with parallel arrays of thin, planar slices of X-ray beams (microplanar beams, or microbeams) spares normal tissue, including the central nervous system (CNS), and preferentially damages tumors. The effects are mediated, at least in part, by the tissue's microvasculature that seems to effectively repair itself in normal tissue but fails to do so in tumors. Consequently, the therapeutic index of single-fraction unidirectional microbeam irradiations has been shown to be larger than that of single-fraction unidirectional unsegmented beams in treating the intracranial rat 9L gliosarcoma tumor model (9LGS) and the subcutaneous murine mammary carcinoma EMT-6. This paper presents results demonstrating that individual microbeams, or arrays of parallel ones, can also be used for targeted, selective cell ablation in the CNS, and also to induce demyelination. The results highlight the value of the method as a powerful tool for studying the CNS through selective cell ablation, besides its potential as a treatment modality in clinical oncology.

Original language	English (US)
Pages (from-to)	30-37
Number of pages	8
Journal	Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume	548
Issue number	1-2
DOIs	https://doi.org/10.1016/j.nima.2005.03.062
State	Published - Aug 11 2005
Event	Proceedings of the 4th International Worhshop on Medical Applications of Synchrotron Radiation MASR 2004 - Duration: Sep 23 2005 → Sep 25 2005

Keywords

Dosimetry
Micro-beam therapy
Synchrotron radiation

ASJC Scopus subject areas

Nuclear and High Energy Physics
Instrumentation

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10.1016/j.nima.2005.03.062

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Dilmanian, F. A., Qu, Y., Liu, S., Cool, C. D., Gilbert, J., Hainfeld, J. F., Kruse, C. A., Laterra, J., Lenihan, D., Nawrocky, M. M., Pappas, G., Sze, C. I., Yuasa, T., Zhong, N., Zhong, Z., & McDonald, J. W. (2005). X-ray microbeams: Tumor therapy and central nervous system research. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 548(1-2), 30-37. https://doi.org/10.1016/j.nima.2005.03.062

Dilmanian, FA, Qu, Y, Liu, S, Cool, CD, Gilbert, J, Hainfeld, JF, Kruse, CA, Laterra, J, Lenihan, D, Nawrocky, MM, Pappas, G, Sze, CI, Yuasa, T, Zhong, N, Zhong, Z & McDonald, JW 2005, 'X-ray microbeams: Tumor therapy and central nervous system research', Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 548, no. 1-2, pp. 30-37. https://doi.org/10.1016/j.nima.2005.03.062

@article{b7bf323101c5459d95c78a1bd9e9d4ec,

title = "X-ray microbeams: Tumor therapy and central nervous system research",

abstract = "Irradiation with parallel arrays of thin, planar slices of X-ray beams (microplanar beams, or microbeams) spares normal tissue, including the central nervous system (CNS), and preferentially damages tumors. The effects are mediated, at least in part, by the tissue's microvasculature that seems to effectively repair itself in normal tissue but fails to do so in tumors. Consequently, the therapeutic index of single-fraction unidirectional microbeam irradiations has been shown to be larger than that of single-fraction unidirectional unsegmented beams in treating the intracranial rat 9L gliosarcoma tumor model (9LGS) and the subcutaneous murine mammary carcinoma EMT-6. This paper presents results demonstrating that individual microbeams, or arrays of parallel ones, can also be used for targeted, selective cell ablation in the CNS, and also to induce demyelination. The results highlight the value of the method as a powerful tool for studying the CNS through selective cell ablation, besides its potential as a treatment modality in clinical oncology.",

keywords = "Dosimetry, Micro-beam therapy, Synchrotron radiation",

author = "Dilmanian, {F. A.} and Y. Qu and S. Liu and Cool, {C. D.} and J. Gilbert and Hainfeld, {J. F.} and Kruse, {C. A.} and J. Laterra and D. Lenihan and Nawrocky, {M. M.} and G. Pappas and Sze, {C. I.} and T. Yuasa and N. Zhong and Z. Zhong and McDonald, {J. W.}",

note = "Funding Information: We thank T. Bacarian, M.E. Berens, A. Feldman, C. Garibotto, T. George, J. Giordano, S. Hussain, Z. Hussain, Y. Kublanskaya, S. Leroy, R. Maehara, P. Mortazavi, A. Nithi, I. Orion, S. Rafiq, B. Ren, E.S. Rosenzweig, J.K. Robinson, A. Ruvinskaya, T. Steidinger, S. Thomas, J. Welwart, D. Williams, A.D. Woodhead, and R. Yakupov for their valuable assistance. These studies were funded by the Nextsteps Foundation, IL (JWM), the National Institute of Health NINDS grants NS37927, NS40520, NS39577 (JWM) and NS43231 (FAD), and the Office of Biological and Environmental Research, U.S. Department of Energy. This research was carried out at the NSLS which is supported by the U.S. Department of Energy, Division of Materials Sciences and Division of Chemical Sciences, under Contract No. DE-AC02-98CH10886. ; Proceedings of the 4th International Worhshop on Medical Applications of Synchrotron Radiation MASR 2004 ; Conference date: 23-09-2005 Through 25-09-2005",

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month = aug,

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doi = "10.1016/j.nima.2005.03.062",

language = "English (US)",

volume = "548",

pages = "30--37",

journal = "Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment",

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TY - JOUR

T1 - X-ray microbeams

T2 - Proceedings of the 4th International Worhshop on Medical Applications of Synchrotron Radiation MASR 2004

AU - Dilmanian, F. A.

AU - Qu, Y.

AU - Liu, S.

AU - Cool, C. D.

AU - Gilbert, J.

AU - Hainfeld, J. F.

AU - Kruse, C. A.

AU - Laterra, J.

AU - Lenihan, D.

AU - Nawrocky, M. M.

AU - Pappas, G.

AU - Sze, C. I.

AU - Yuasa, T.

AU - Zhong, N.

AU - Zhong, Z.

AU - McDonald, J. W.

N1 - Funding Information: We thank T. Bacarian, M.E. Berens, A. Feldman, C. Garibotto, T. George, J. Giordano, S. Hussain, Z. Hussain, Y. Kublanskaya, S. Leroy, R. Maehara, P. Mortazavi, A. Nithi, I. Orion, S. Rafiq, B. Ren, E.S. Rosenzweig, J.K. Robinson, A. Ruvinskaya, T. Steidinger, S. Thomas, J. Welwart, D. Williams, A.D. Woodhead, and R. Yakupov for their valuable assistance. These studies were funded by the Nextsteps Foundation, IL (JWM), the National Institute of Health NINDS grants NS37927, NS40520, NS39577 (JWM) and NS43231 (FAD), and the Office of Biological and Environmental Research, U.S. Department of Energy. This research was carried out at the NSLS which is supported by the U.S. Department of Energy, Division of Materials Sciences and Division of Chemical Sciences, under Contract No. DE-AC02-98CH10886.

PY - 2005/8/11

Y1 - 2005/8/11

N2 - Irradiation with parallel arrays of thin, planar slices of X-ray beams (microplanar beams, or microbeams) spares normal tissue, including the central nervous system (CNS), and preferentially damages tumors. The effects are mediated, at least in part, by the tissue's microvasculature that seems to effectively repair itself in normal tissue but fails to do so in tumors. Consequently, the therapeutic index of single-fraction unidirectional microbeam irradiations has been shown to be larger than that of single-fraction unidirectional unsegmented beams in treating the intracranial rat 9L gliosarcoma tumor model (9LGS) and the subcutaneous murine mammary carcinoma EMT-6. This paper presents results demonstrating that individual microbeams, or arrays of parallel ones, can also be used for targeted, selective cell ablation in the CNS, and also to induce demyelination. The results highlight the value of the method as a powerful tool for studying the CNS through selective cell ablation, besides its potential as a treatment modality in clinical oncology.

AB - Irradiation with parallel arrays of thin, planar slices of X-ray beams (microplanar beams, or microbeams) spares normal tissue, including the central nervous system (CNS), and preferentially damages tumors. The effects are mediated, at least in part, by the tissue's microvasculature that seems to effectively repair itself in normal tissue but fails to do so in tumors. Consequently, the therapeutic index of single-fraction unidirectional microbeam irradiations has been shown to be larger than that of single-fraction unidirectional unsegmented beams in treating the intracranial rat 9L gliosarcoma tumor model (9LGS) and the subcutaneous murine mammary carcinoma EMT-6. This paper presents results demonstrating that individual microbeams, or arrays of parallel ones, can also be used for targeted, selective cell ablation in the CNS, and also to induce demyelination. The results highlight the value of the method as a powerful tool for studying the CNS through selective cell ablation, besides its potential as a treatment modality in clinical oncology.

KW - Dosimetry

KW - Micro-beam therapy

KW - Synchrotron radiation

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UR - http://www.scopus.com/inward/citedby.url?scp=23144441479&partnerID=8YFLogxK

U2 - 10.1016/j.nima.2005.03.062

DO - 10.1016/j.nima.2005.03.062

M3 - Conference article

C2 - 17369874

AN - SCOPUS:23144441479

SN - 0168-9002

VL - 548

SP - 30

EP - 37

JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

IS - 1-2

Y2 - 23 September 2005 through 25 September 2005

ER -

X-ray microbeams: Tumor therapy and central nervous system research

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Keywords

ASJC Scopus subject areas

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