X-linked 6-phosphogluconate dehydrogenase in Drosophila: Subunit associations

H. H. Kazazian; W. J. Young; B. Childs

doi:10.1126/science.150.3703.1601

X-linked 6-phosphogluconate dehydrogenase in Drosophila: Subunit associations

H. H. Kazazian, W. J. Young, B. Childs

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Abstract

6-Phosphogluconate dehydrogenase (PGD) subunits have been dissociated and reassociated in vitro. The intermediate PGD of the heterozygous phenotype is reproduced by reassociation in vitro of subunits derived from the two types of PGD from homozygous flies. This result has a bearing on gene action in the diploid organism and on the mechanism of dosage compensation in Drosophila melanogaster.

Original language	English (US)
Pages (from-to)	1601-1602
Number of pages	2
Journal	Science
Volume	150
Issue number	3703
DOIs	https://doi.org/10.1126/science.150.3703.1601
State	Published - 1965
Externally published	Yes

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title = "X-linked 6-phosphogluconate dehydrogenase in Drosophila: Subunit associations",

abstract = "6-Phosphogluconate dehydrogenase (PGD) subunits have been dissociated and reassociated in vitro. The intermediate PGD of the heterozygous phenotype is reproduced by reassociation in vitro of subunits derived from the two types of PGD from homozygous flies. This result has a bearing on gene action in the diploid organism and on the mechanism of dosage compensation in Drosophila melanogaster.",

author = "Kazazian, {H. H.} and Young, {W. J.} and B. Childs",

year = "1965",

doi = "10.1126/science.150.3703.1601",

language = "English (US)",

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T1 - X-linked 6-phosphogluconate dehydrogenase in Drosophila

T2 - Subunit associations

AU - Kazazian, H. H.

AU - Young, W. J.

AU - Childs, B.

PY - 1965

Y1 - 1965

N2 - 6-Phosphogluconate dehydrogenase (PGD) subunits have been dissociated and reassociated in vitro. The intermediate PGD of the heterozygous phenotype is reproduced by reassociation in vitro of subunits derived from the two types of PGD from homozygous flies. This result has a bearing on gene action in the diploid organism and on the mechanism of dosage compensation in Drosophila melanogaster.

AB - 6-Phosphogluconate dehydrogenase (PGD) subunits have been dissociated and reassociated in vitro. The intermediate PGD of the heterozygous phenotype is reproduced by reassociation in vitro of subunits derived from the two types of PGD from homozygous flies. This result has a bearing on gene action in the diploid organism and on the mechanism of dosage compensation in Drosophila melanogaster.

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X-linked 6-phosphogluconate dehydrogenase in Drosophila: Subunit associations

Abstract

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