X-chromosome inactivation: molecular mechanisms and genetic consequences

Barbara R. Migeon

doi:10.1016/0168-9525(94)90169-4

X-chromosome inactivation: molecular mechanisms and genetic consequences

Barbara R. Migeon

School of Medicine

Research output: Contribution to journal › Review article › peer-review

98 Scopus citations

Abstract

Mammalian X-chromosome inactivation results in dosage compensation for X-linked genes. More than 30 years after its discovery, the molecular bases of this inactivation are being revealed. Multiple mechanisms are responsible for the initiation of this developmental event and the maintenance of the inactive state. Somatic cellular mosaicism, which is the genetic consequence of X-chromosome inactivation, has a profound influence on the phenotype of mammalian females.

Original language	English (US)
Pages (from-to)	230-235
Number of pages	6
Journal	Trends in Genetics
Volume	10
Issue number	7
DOIs	https://doi.org/10.1016/0168-9525(94)90169-4
State	Published - Jul 1994

ASJC Scopus subject areas

Genetics

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10.1016/0168-9525(94)90169-4

Cite this

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title = "X-chromosome inactivation: molecular mechanisms and genetic consequences",

abstract = "Mammalian X-chromosome inactivation results in dosage compensation for X-linked genes. More than 30 years after its discovery, the molecular bases of this inactivation are being revealed. Multiple mechanisms are responsible for the initiation of this developmental event and the maintenance of the inactive state. Somatic cellular mosaicism, which is the genetic consequence of X-chromosome inactivation, has a profound influence on the phenotype of mammalian females.",

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AB - Mammalian X-chromosome inactivation results in dosage compensation for X-linked genes. More than 30 years after its discovery, the molecular bases of this inactivation are being revealed. Multiple mechanisms are responsible for the initiation of this developmental event and the maintenance of the inactive state. Somatic cellular mosaicism, which is the genetic consequence of X-chromosome inactivation, has a profound influence on the phenotype of mammalian females.

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X-chromosome inactivation: molecular mechanisms and genetic consequences

Abstract

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