X chromosomal abnormalities in basal-like human breast cancer

Andrea Richardson, Zhigang C. Wang, Arcangela De Nicolo, Xin Lu, Myles Brown, Alexander Miron, Xiaodong Liao, J. Dirk Iglehart, David M. Livingston, Shridar Ganesan

Research output: Contribution to journalArticle

Abstract

Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosome transcription but were associated with overexpression of a small subset of X chromosomal genes. Other, equally aneuploid, but non-BLC rarely displayed these X chromosome abnormalities. These results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic.

Original languageEnglish (US)
Pages (from-to)121-132
Number of pages12
JournalCancer Cell
Volume9
Issue number2
DOIs
StatePublished - Feb 2006
Externally publishedYes

Fingerprint

Chromosome Aberrations
X Chromosome
Breast Neoplasms
Neoplasms
Aneuploidy
DNA
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

Richardson, A., Wang, Z. C., De Nicolo, A., Lu, X., Brown, M., Miron, A., ... Ganesan, S. (2006). X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell, 9(2), 121-132. https://doi.org/10.1016/j.ccr.2006.01.013

X chromosomal abnormalities in basal-like human breast cancer. / Richardson, Andrea; Wang, Zhigang C.; De Nicolo, Arcangela; Lu, Xin; Brown, Myles; Miron, Alexander; Liao, Xiaodong; Iglehart, J. Dirk; Livingston, David M.; Ganesan, Shridar.

In: Cancer Cell, Vol. 9, No. 2, 02.2006, p. 121-132.

Research output: Contribution to journalArticle

Richardson, A, Wang, ZC, De Nicolo, A, Lu, X, Brown, M, Miron, A, Liao, X, Iglehart, JD, Livingston, DM & Ganesan, S 2006, 'X chromosomal abnormalities in basal-like human breast cancer', Cancer Cell, vol. 9, no. 2, pp. 121-132. https://doi.org/10.1016/j.ccr.2006.01.013
Richardson, Andrea ; Wang, Zhigang C. ; De Nicolo, Arcangela ; Lu, Xin ; Brown, Myles ; Miron, Alexander ; Liao, Xiaodong ; Iglehart, J. Dirk ; Livingston, David M. ; Ganesan, Shridar. / X chromosomal abnormalities in basal-like human breast cancer. In: Cancer Cell. 2006 ; Vol. 9, No. 2. pp. 121-132.
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