Abstract
Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosome transcription but were associated with overexpression of a small subset of X chromosomal genes. Other, equally aneuploid, but non-BLC rarely displayed these X chromosome abnormalities. These results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 121-132 |
| Number of pages | 12 |
| Journal | Cancer Cell |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2006 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Cancer Research
- Cell Biology
- Oncology
Cite this
X chromosomal abnormalities in basal-like human breast cancer. / Richardson, Andrea; Wang, Zhigang C.; De Nicolo, Arcangela; Lu, Xin; Brown, Myles; Miron, Alexander; Liao, Xiaodong; Iglehart, J. Dirk; Livingston, David M.; Ganesan, Shridar.
In: Cancer Cell, Vol. 9, No. 2, 02.2006, p. 121-132.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - X chromosomal abnormalities in basal-like human breast cancer
AU - Richardson, Andrea
AU - Wang, Zhigang C.
AU - De Nicolo, Arcangela
AU - Lu, Xin
AU - Brown, Myles
AU - Miron, Alexander
AU - Liao, Xiaodong
AU - Iglehart, J. Dirk
AU - Livingston, David M.
AU - Ganesan, Shridar
PY - 2006/2
Y1 - 2006/2
N2 - Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosome transcription but were associated with overexpression of a small subset of X chromosomal genes. Other, equally aneuploid, but non-BLC rarely displayed these X chromosome abnormalities. These results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic.
AB - Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosome transcription but were associated with overexpression of a small subset of X chromosomal genes. Other, equally aneuploid, but non-BLC rarely displayed these X chromosome abnormalities. These results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic.
UR - http://www.scopus.com/inward/record.url?scp=32044453343&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=32044453343&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2006.01.013
DO - 10.1016/j.ccr.2006.01.013
M3 - Article
C2 - 16473279
AN - SCOPUS:32044453343
VL - 9
SP - 121
EP - 132
JO - Cancer Cell
JF - Cancer Cell
SN - 1535-6108
IS - 2
ER -