X chromosomal abnormalities in basal-like human breast cancer

Andrea L. Richardson, Zhigang C. Wang, Arcangela De Nicolo, Xin Lu, Myles Brown, Alexander Miron, Xiaodong Liao, J. Dirk Iglehart, David M. Livingston, Shridar Ganesan

Research output: Contribution to journalArticlepeer-review

Abstract

Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosome transcription but were associated with overexpression of a small subset of X chromosomal genes. Other, equally aneuploid, but non-BLC rarely displayed these X chromosome abnormalities. These results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic.

Original languageEnglish (US)
Pages (from-to)121-132
Number of pages12
JournalCancer cell
Volume9
Issue number2
DOIs
StatePublished - Feb 2006

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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