WT1 expression at diagnosis does not predict survival in pediatric AML: A report from the children's oncology group

Suzie A. Noronha, Jason E. Farrar, Todd A. Alonzo, Robert B. Gerbing, Norman J. Lacayo, Gary V. Dahl, Yaddanapudi Ravindranath, Robert J. Arceci, David M. Loeb

Research output: Contribution to journalArticle

Abstract

WT1 is a transcription factor that is aberrantly overexpressed in acute and chronic leukemias. Overexpression of WT1 in pediatric acute myeloid leukemia has been reported, but the prognostic significance is unclear because sample sizes in these studies have been relatively small. WT1 expression was measured by quantitative RT-PCR in samples obtained at diagnosis from 155 pediatric AML patients treated on a cooperative group protocol. Neither overall survival nor event-free survival was correlated with WT1 expression.

Original languageEnglish (US)
Pages (from-to)1136-1139
Number of pages4
JournalPediatric Blood and Cancer
Volume53
Issue number6
DOIs
StatePublished - 2009

Keywords

  • Acute myeloid leukemia
  • Prognosis
  • Prognostic factor
  • Wilms tumor 1

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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  • Cite this

    Noronha, S. A., Farrar, J. E., Alonzo, T. A., Gerbing, R. B., Lacayo, N. J., Dahl, G. V., Ravindranath, Y., Arceci, R. J., & Loeb, D. M. (2009). WT1 expression at diagnosis does not predict survival in pediatric AML: A report from the children's oncology group. Pediatric Blood and Cancer, 53(6), 1136-1139. https://doi.org/10.1002/pbc.22142