Abstract
The effects of oral and topical application of Calendula officinalis flower extract on excision wounds made in rats were checked. The parameters assessed were the days needed for re-epithelization and percentage of wound closure. The hydroxy proline and hexosamine content in the granuloma tissue of the wound was also measured. The percentage of wound closure was 90.0% in the extract-treated group, whereas the control group showed only 51.1% on the eighth day of wounding (p <.01). The days needed for re-epithelization were 17.7 for the control animals; extract treatment at a dose of 20 or 100 mg/kg b.wt reduced the period to 14 and 13 days, respectively, A significant increase was observed in the hydroxy proline and hexosamine content in the extract-treated group compared with the untreated animals. The data indicate potent wound healing activity ofC. officinalis extract.
Original language | English (US) |
---|---|
Pages (from-to) | 73-80 |
Number of pages | 8 |
Journal | Journal of Basic and Clinical Physiology and Pharmacology |
Volume | 20 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2009 |
Externally published | Yes |
Keywords
- Calendula officinalis
- antioxidant
- hexosamine
- hydroxy proline
- wound healing
ASJC Scopus subject areas
- Physiology
- Pharmacology
- Drug Discovery