Worthy of further consideration: An updated meta-analysis to address the feasibility, acceptability, safety and efficacy of thermal ablation in the treatment of cervical cancer precursor lesions

Thomas C. Randall, Catherine Sauvaget, Richard Muwonge, Edward Trimble, Jose Jeronimo

Research output: Contribution to journalReview article

Abstract

Treatment of preinvasive lesions is critical to the success of secondary prevention of cervical cancer. In many settings, however, excision or ablation of preinvasive lesions can prove challenging. Thermal ablation (TA) is a form of treatment for cervical precancer that may present fewer logistical challenges in resource limited settings. In 2013, Dolman and colleagues wrote a meta-analysis of publications reporting cure rates from TA. This included only one article from a low or middle-income country (LMIC). We updated Dolman's meta-analysis to include more recent articles from LMICs. A formal review of the world literature was performed for the years 2014–2017. Article titles and abstracts were reviewed for relevance; full articles were assessed for quality. The primary endpoint was treatment outcome for cervical intraepithelial neoplasia grade 2 or higher (CIN2+). The I2 statistic was used to assess heterogeneity between studies. Studies were stratified by geographic region, decade that the study was published, World Bank economic classification of the country where the study was performed, and other factors. We reviewed 34 total reports and included 23 in our meta-analysis, including 10,995 and 6371 patients, respectively. A total of 7 studies were performed in LMICs, including 6 studies included in the meta-analysis. The overall response rate for TA treatment of biopsy proven CIN2+ was 93.8%. Consistent with the wide variety of settings and patient populations, there was significant heterogeneity between studies. TA appears to be an effective treatment for CIN2+ across a variety of settings, including in LMICs.

LanguageEnglish (US)
Pages81-91
Number of pages11
JournalPreventive Medicine
Volume118
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Fingerprint

Uterine Cervical Neoplasms
Meta-Analysis
Hot Temperature
Safety
Cervical Intraepithelial Neoplasia
United Nations
Therapeutics
Secondary Prevention
Publications
Economics
Biopsy
Population

Keywords

  • Ablation
  • Cervical cancer screening
  • Secondary prevention
  • Uterine cervical dysplasia

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Worthy of further consideration : An updated meta-analysis to address the feasibility, acceptability, safety and efficacy of thermal ablation in the treatment of cervical cancer precursor lesions. / Randall, Thomas C.; Sauvaget, Catherine; Muwonge, Richard; Trimble, Edward; Jeronimo, Jose.

In: Preventive Medicine, Vol. 118, 01.01.2019, p. 81-91.

Research output: Contribution to journalReview article

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