TY - JOUR
T1 - Worse in-hospital outcomes in patients with transient ischemic attack in association with acute kidney injury
T2 - Analysis of nationwide in-patient sample
AU - Saeed, Fahad
AU - Adil, Malik M.
AU - Malik, Ahmed A.
AU - Qureshi, Mushtaq H.
AU - Nahab, Fadi
N1 - Publisher Copyright:
© 2014 S. Karger AG, Basel.
PY - 2014/11/13
Y1 - 2014/11/13
N2 - Objectives: The effect of acute kidney injury (AKI) on outcomes of transient ischemic attack (TIA) is largely unknown. We wanted to determine the impact of AKI on the outcomes of patients admitted with TIA. Methods: Data from all adult patients admitted to the U.S. hospitals between 2005 and 2011 with a primary discharge diagnosis of TIA and secondary diagnosis of AKI were included, using the nationwide inpatient dataset. The association of AKI with TIA-related mortality and discharge outcomes was analyzed after adjusting for potential confounders using logistic regression analysis. Results: Of the 1,173,340 patients admitted with TIA, 45,974 (3.8%) had AKI. Dialysis was required in 29 (0.06%) patients. TIA patients with AKI had higher rates of moderate-to-severe disability (21.2 vs. 13.7%, p ≤ 0.0001), and in-hospital mortality (0.6 vs. 0.1%, p ≤ 0.0001) compared with those without AKI. After adjusting for age, sex, and potential confounders; TIA patients with AKI had higher odds of moderate-to-severe disability [OR 1.3, 95% CI 1.2-1.4, p < 0.0001] and death (OR 4.2, 95% CI 3.0-6.1, p < 0.0001). Conclusions: AKI in patients with TIA is associated with significantly higher rates of moderate- to-severe disability at discharge and in-hospital mortality compared with those without AKI.
AB - Objectives: The effect of acute kidney injury (AKI) on outcomes of transient ischemic attack (TIA) is largely unknown. We wanted to determine the impact of AKI on the outcomes of patients admitted with TIA. Methods: Data from all adult patients admitted to the U.S. hospitals between 2005 and 2011 with a primary discharge diagnosis of TIA and secondary diagnosis of AKI were included, using the nationwide inpatient dataset. The association of AKI with TIA-related mortality and discharge outcomes was analyzed after adjusting for potential confounders using logistic regression analysis. Results: Of the 1,173,340 patients admitted with TIA, 45,974 (3.8%) had AKI. Dialysis was required in 29 (0.06%) patients. TIA patients with AKI had higher rates of moderate-to-severe disability (21.2 vs. 13.7%, p ≤ 0.0001), and in-hospital mortality (0.6 vs. 0.1%, p ≤ 0.0001) compared with those without AKI. After adjusting for age, sex, and potential confounders; TIA patients with AKI had higher odds of moderate-to-severe disability [OR 1.3, 95% CI 1.2-1.4, p < 0.0001] and death (OR 4.2, 95% CI 3.0-6.1, p < 0.0001). Conclusions: AKI in patients with TIA is associated with significantly higher rates of moderate- to-severe disability at discharge and in-hospital mortality compared with those without AKI.
KW - Acute kidney injury
KW - Transient ischemic attack
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U2 - 10.1159/000367855
DO - 10.1159/000367855
M3 - Article
C2 - 25322955
AN - SCOPUS:84908271123
SN - 0250-8095
VL - 40
SP - 258
EP - 262
JO - American Journal of Nephrology
JF - American Journal of Nephrology
IS - 3
ER -