Worldwide prevalence of lentivirus infection in wild feline species: Epidemiologic and phylogenetic aspects

Robert A. Olmsted, Raymond Langley, Melody E. Roelke, Robert M. Goeken, Diane Adger-Johnson, Julie P. Goff, John P. Albert, Craig Packer, M. Karen Laurenson, Tim M. Caro, Lue Scheepers, David E. Wildt, Mitchell Bush, Janice S. Martenson, Stephen J. O'Brien

Research output: Contribution to journalArticle

Abstract

The natural occurrence of lentiviruses closely related to feline immunodeficiency virus (FIV) in nondomestic felid species is shown here to be worldwide. Cross-reactive antibodies to FIV were common in several free-ranging populations of large cats, including East African lions and cheetahs of the Serengeti ecosystem and in puma (also called cougar or mountain lion) populations throughout North America. Infectious puma lentivirus (PLV) was isolated from several Florida panthers, a severely endangered relict puma subspecies inhabiting the Big Cypress Swamp and Everglades ecosystems in southern Florida. Phylogenetic analysis of PLV genomic sequences from disparate geographic isolates revealed appreciable divergence from domestic cat FIV sequences as well as between PLV sequences found in different North American locales. The level of sequence divergence between PLV and FIV was greater than the level of divergence between human and certain simian immunodeficiency viruses, suggesting that the transmission of FIV between feline species is infrequent and parallels in time the emergence of HIV from simian ancestors.

Original languageEnglish (US)
Pages (from-to)6008-6018
Number of pages11
JournalJournal of Virology
Volume66
Issue number10
StatePublished - Oct 1992
Externally publishedYes

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Lentivirus Infections
Puma lentivirus
Feline Immunodeficiency Virus
Lentivirus
Feline immunodeficiency virus
Felidae
Puma
cats
phylogeny
Puma concolor
infection
Simian immunodeficiency virus
Acinonyx jubatus
ecosystems
Panthera leo
virus transmission
swamps
Ecosystem
Cats
Acinonyx

ASJC Scopus subject areas

  • Immunology

Cite this

Olmsted, R. A., Langley, R., Roelke, M. E., Goeken, R. M., Adger-Johnson, D., Goff, J. P., ... O'Brien, S. J. (1992). Worldwide prevalence of lentivirus infection in wild feline species: Epidemiologic and phylogenetic aspects. Journal of Virology, 66(10), 6008-6018.

Worldwide prevalence of lentivirus infection in wild feline species : Epidemiologic and phylogenetic aspects. / Olmsted, Robert A.; Langley, Raymond; Roelke, Melody E.; Goeken, Robert M.; Adger-Johnson, Diane; Goff, Julie P.; Albert, John P.; Packer, Craig; Laurenson, M. Karen; Caro, Tim M.; Scheepers, Lue; Wildt, David E.; Bush, Mitchell; Martenson, Janice S.; O'Brien, Stephen J.

In: Journal of Virology, Vol. 66, No. 10, 10.1992, p. 6008-6018.

Research output: Contribution to journalArticle

Olmsted, RA, Langley, R, Roelke, ME, Goeken, RM, Adger-Johnson, D, Goff, JP, Albert, JP, Packer, C, Laurenson, MK, Caro, TM, Scheepers, L, Wildt, DE, Bush, M, Martenson, JS & O'Brien, SJ 1992, 'Worldwide prevalence of lentivirus infection in wild feline species: Epidemiologic and phylogenetic aspects', Journal of Virology, vol. 66, no. 10, pp. 6008-6018.
Olmsted RA, Langley R, Roelke ME, Goeken RM, Adger-Johnson D, Goff JP et al. Worldwide prevalence of lentivirus infection in wild feline species: Epidemiologic and phylogenetic aspects. Journal of Virology. 1992 Oct;66(10):6008-6018.
Olmsted, Robert A. ; Langley, Raymond ; Roelke, Melody E. ; Goeken, Robert M. ; Adger-Johnson, Diane ; Goff, Julie P. ; Albert, John P. ; Packer, Craig ; Laurenson, M. Karen ; Caro, Tim M. ; Scheepers, Lue ; Wildt, David E. ; Bush, Mitchell ; Martenson, Janice S. ; O'Brien, Stephen J. / Worldwide prevalence of lentivirus infection in wild feline species : Epidemiologic and phylogenetic aspects. In: Journal of Virology. 1992 ; Vol. 66, No. 10. pp. 6008-6018.
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