Worldwide prevalence of lentivirus infection in wild feline species: Epidemiologic and phylogenetic aspects

Robert A. Olmsted; Raymond Langley; Melody E. Roelke; Robert M. Goeken; Diane Adger-Johnson; Julie P. Goff; John P. Albert; Craig Packer; M. Karen Laurenson; Tim M. Caro; Lue Scheepers; David E. Wildt; Mitchell Bush; Janice S. Martenson; Stephen J. O'Brien

Worldwide prevalence of lentivirus infection in wild feline species: Epidemiologic and phylogenetic aspects

Robert A. Olmsted, Raymond Langley, Melody E. Roelke, Robert M. Goeken, Diane Adger-Johnson, Julie P. Goff, John P. Albert, Craig Packer, M. Karen Laurenson, Tim M. Caro, Lue Scheepers, David E. Wildt, Mitchell Bush, Janice S. Martenson, Stephen J. O'Brien

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

The natural occurrence of lentiviruses closely related to feline immunodeficiency virus (FIV) in nondomestic felid species is shown here to be worldwide. Cross-reactive antibodies to FIV were common in several free-ranging populations of large cats, including East African lions and cheetahs of the Serengeti ecosystem and in puma (also called cougar or mountain lion) populations throughout North America. Infectious puma lentivirus (PLV) was isolated from several Florida panthers, a severely endangered relict puma subspecies inhabiting the Big Cypress Swamp and Everglades ecosystems in southern Florida. Phylogenetic analysis of PLV genomic sequences from disparate geographic isolates revealed appreciable divergence from domestic cat FIV sequences as well as between PLV sequences found in different North American locales. The level of sequence divergence between PLV and FIV was greater than the level of divergence between human and certain simian immunodeficiency viruses, suggesting that the transmission of FIV between feline species is infrequent and parallels in time the emergence of HIV from simian ancestors.

Original language	English (US)
Pages (from-to)	6008-6018
Number of pages	11
Journal	Journal of virology
Volume	66
Issue number	10
State	Published - Oct 1992
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

Cite this

Olmsted, R. A., Langley, R., Roelke, M. E., Goeken, R. M., Adger-Johnson, D., Goff, J. P., Albert, J. P., Packer, C., Laurenson, M. K., Caro, T. M., Scheepers, L., Wildt, D. E., Bush, M., Martenson, J. S., & O'Brien, S. J. (1992). Worldwide prevalence of lentivirus infection in wild feline species: Epidemiologic and phylogenetic aspects. Journal of virology, 66(10), 6008-6018.

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title = "Worldwide prevalence of lentivirus infection in wild feline species: Epidemiologic and phylogenetic aspects",

abstract = "The natural occurrence of lentiviruses closely related to feline immunodeficiency virus (FIV) in nondomestic felid species is shown here to be worldwide. Cross-reactive antibodies to FIV were common in several free-ranging populations of large cats, including East African lions and cheetahs of the Serengeti ecosystem and in puma (also called cougar or mountain lion) populations throughout North America. Infectious puma lentivirus (PLV) was isolated from several Florida panthers, a severely endangered relict puma subspecies inhabiting the Big Cypress Swamp and Everglades ecosystems in southern Florida. Phylogenetic analysis of PLV genomic sequences from disparate geographic isolates revealed appreciable divergence from domestic cat FIV sequences as well as between PLV sequences found in different North American locales. The level of sequence divergence between PLV and FIV was greater than the level of divergence between human and certain simian immunodeficiency viruses, suggesting that the transmission of FIV between feline species is infrequent and parallels in time the emergence of HIV from simian ancestors.",

author = "Olmsted, {Robert A.} and Raymond Langley and Roelke, {Melody E.} and Goeken, {Robert M.} and Diane Adger-Johnson and Goff, {Julie P.} and Albert, {John P.} and Craig Packer and Laurenson, {M. Karen} and Caro, {Tim M.} and Lue Scheepers and Wildt, {David E.} and Mitchell Bush and Martenson, {Janice S.} and O'Brien, {Stephen J.}",

year = "1992",

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language = "English (US)",

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AU - Olmsted, Robert A.

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AU - Roelke, Melody E.

AU - Goeken, Robert M.

AU - Adger-Johnson, Diane

AU - Goff, Julie P.

AU - Albert, John P.

AU - Packer, Craig

AU - Laurenson, M. Karen

AU - Caro, Tim M.

AU - Scheepers, Lue

AU - Wildt, David E.

AU - Bush, Mitchell

AU - Martenson, Janice S.

AU - O'Brien, Stephen J.

PY - 1992/10

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N2 - The natural occurrence of lentiviruses closely related to feline immunodeficiency virus (FIV) in nondomestic felid species is shown here to be worldwide. Cross-reactive antibodies to FIV were common in several free-ranging populations of large cats, including East African lions and cheetahs of the Serengeti ecosystem and in puma (also called cougar or mountain lion) populations throughout North America. Infectious puma lentivirus (PLV) was isolated from several Florida panthers, a severely endangered relict puma subspecies inhabiting the Big Cypress Swamp and Everglades ecosystems in southern Florida. Phylogenetic analysis of PLV genomic sequences from disparate geographic isolates revealed appreciable divergence from domestic cat FIV sequences as well as between PLV sequences found in different North American locales. The level of sequence divergence between PLV and FIV was greater than the level of divergence between human and certain simian immunodeficiency viruses, suggesting that the transmission of FIV between feline species is infrequent and parallels in time the emergence of HIV from simian ancestors.

AB - The natural occurrence of lentiviruses closely related to feline immunodeficiency virus (FIV) in nondomestic felid species is shown here to be worldwide. Cross-reactive antibodies to FIV were common in several free-ranging populations of large cats, including East African lions and cheetahs of the Serengeti ecosystem and in puma (also called cougar or mountain lion) populations throughout North America. Infectious puma lentivirus (PLV) was isolated from several Florida panthers, a severely endangered relict puma subspecies inhabiting the Big Cypress Swamp and Everglades ecosystems in southern Florida. Phylogenetic analysis of PLV genomic sequences from disparate geographic isolates revealed appreciable divergence from domestic cat FIV sequences as well as between PLV sequences found in different North American locales. The level of sequence divergence between PLV and FIV was greater than the level of divergence between human and certain simian immunodeficiency viruses, suggesting that the transmission of FIV between feline species is infrequent and parallels in time the emergence of HIV from simian ancestors.

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Worldwide prevalence of lentivirus infection in wild feline species: Epidemiologic and phylogenetic aspects

Abstract

ASJC Scopus subject areas

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