Worldwide incidence of cervical lesions: A systematic review

J. Ting, A. F. Rositch, S. M. Taylor, L. Rahangdale, H. M. Soeters, X. Sun, J. S. Smith

Research output: Contribution to journalReview article

Abstract

We conducted a systematic review summarizing data on incidence of high- and low-grade lesions in women with normal baseline cervical cytology, stratified by age (<30 and ≥30 years), and baseline human papillomavirus (HPV) infection. Incidence of high- and low-grade lesions in women aged ≥30 years with a baseline HPV infection increased over follow-up time (5-127 months), although incidence generally remained <10%. Without baseline HPV infection, incidence of high-grade lesions remained low over follow-up time (<5% over 5-122 months). Incidence of high-grade lesions in women aged ≥30 years with baseline HPV infection appeared similar to that in women aged <30 years. In some women aged <30 years, high-grade lesions can develop relatively shortly after initial HPV infection. We observed an increase in low-grade lesions over time in women aged ≥30 years with baseline HPV infection, potentially indicative of an HPV infection that is potentially progressing to higher grade lesions.

Original languageEnglish (US)
Pages (from-to)225-241
Number of pages17
JournalEpidemiology and infection
Volume143
Issue number2
DOIs
StatePublished - Jan 12 2015

Keywords

  • Epidemiology
  • human papilloma virus (HPV)

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases

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    Ting, J., Rositch, A. F., Taylor, S. M., Rahangdale, L., Soeters, H. M., Sun, X., & Smith, J. S. (2015). Worldwide incidence of cervical lesions: A systematic review. Epidemiology and infection, 143(2), 225-241. https://doi.org/10.1017/S0950268814001356