World Health Organization Generic Protocol to Assess Drug-Resistant HIV among Children

Silvia Bertagnolio, Martina Penazzato, Michael R. Jordan, Deborah Persaud, Lynne M. Mofenson, Diane E. Bennett

Research output: Contribution to journalArticle

Abstract

Increased use of nonnucleoside reverse transcriptase inhibitors (NNRTIs) in pregnant and breastfeeding women will result in fewer children infected with human immunodeficiency virus (HIV). However, among children infected despite prevention of mother-to-child transmission (PMTCT), a substantial proportion will acquire NNRTI-resistant HIV, potentially compromising response to NNRTI-based antiretroviral therapy (ART). In countries scaling up PMTCT and pediatric ART programs, it is crucial to assess the proportion of young children with drug-resistant HIV to improve health outcomes and support national and global decision making on optimal selection of pediatric first-line ART. This article summarizes a new World Health Organization surveillance protocol to assess resistance using remnant dried blood spot specimens from a representative sample of children aged

Original languageEnglish (US)
JournalClinical Infectious Diseases
Volume54
Issue numberSUPPL. 4
DOIs
StatePublished - May 15 2012

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HIV
Reverse Transcriptase Inhibitors
Pharmaceutical Preparations
Mothers
Pediatrics
Breast Feeding
Pregnant Women
Decision Making
Therapeutics
Health

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

World Health Organization Generic Protocol to Assess Drug-Resistant HIV among Children . / Bertagnolio, Silvia; Penazzato, Martina; Jordan, Michael R.; Persaud, Deborah; Mofenson, Lynne M.; Bennett, Diane E.

In: Clinical Infectious Diseases, Vol. 54, No. SUPPL. 4, 15.05.2012.

Research output: Contribution to journalArticle

Bertagnolio, Silvia ; Penazzato, Martina ; Jordan, Michael R. ; Persaud, Deborah ; Mofenson, Lynne M. ; Bennett, Diane E. / World Health Organization Generic Protocol to Assess Drug-Resistant HIV among Children . In: Clinical Infectious Diseases. 2012 ; Vol. 54, No. SUPPL. 4.
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