Workshop report: Developing microphysiological systems for use as regulatory tools

Melvin E. Andersen, Kellyn Betts, Yvonne Dragan, Suzanne Fitzpatrick, Jesse L. Goodman, Thomas Hartung, Jonathan Himmelfarb, Donald E. Ingber, Abigail Jacobs, Robert Kavlock, Kyle Kolaja, James L. Stevens, Dan Tagle, D. Lansing Taylor, Douglas Throckmorton

Research output: Contribution to journalReview article

Abstract

In the last few years, scientists have made progress in developing systems using human cells to test the effects of drugs and other substances. These systems are known as microsystems, microphysiological systems, or organs-on-a-chip. They have the potential to improve toxicity testing beyond currently available tools and to reduce the number of animals used. On May 10, 2013 scientists in academia, industry and regulatory agencies met in person and online to discuss the essential elements needed to develop these systems for use as regulatory tools, as well as pathways to their qualification. The one-day workshop was co-sponsored by the Food and Drug Administration, National Institutes of Health, National Institute for Environmental Health Sciences, National Center for Advancing Translational Science, Environmental Protection Agency, Johns Hopkins School of Public Health's Center for Alternatives to Animal Testing and the International Consortium for Innovation and Quality in Pharmaceutical Development.

Original languageEnglish (US)
JournalALTEX
Volume31
DOIs
StatePublished - Jan 1 2014

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Keywords

  • Microphysiological systems
  • Organs-on-a-chip

ASJC Scopus subject areas

  • Pharmacology
  • Medical Laboratory Technology

Cite this

Andersen, M. E., Betts, K., Dragan, Y., Fitzpatrick, S., Goodman, J. L., Hartung, T., Himmelfarb, J., Ingber, D. E., Jacobs, A., Kavlock, R., Kolaja, K., Stevens, J. L., Tagle, D., Taylor, D. L., & Throckmorton, D. (2014). Workshop report: Developing microphysiological systems for use as regulatory tools. ALTEX, 31. https://doi.org/10.14573/altex.1405151s