Working plan for the use of patient-reported outcome measures in adults with brain tumours: a Response Assessment in Neuro-Oncology (RANO) initiative

Linda Dirven, Terri S. Armstrong, Jaishri Blakeley, Paul D. Brown, Robin Grant, Rakesh Jalali, Heather Leeper, Tito Mendoza, Lakshmi Nayak, Jaap C. Reijneveld, Emilie Le Rhun, Tobias Walbert, Michael Weller, Patrick Y. Wen, Martin J.B. Taphoorn

Research output: Contribution to journalReview article

Abstract

The Response Assessment in Neuro-Oncology-Patient-Reported Outcome (RANO-PRO) working group is an international multidisciplinary collaboration that provides guidance on the use of patient-reported outcome (PRO) measures in clinical trials and practice for adult patients with brain tumours. Findings from both PROs and traditional outcome measures, such as survival, and clinical or radiological response, are essential to inform the research community, policy makers, physicians, and patients in the treatment decision-making process. Previous initiatives in oncology have focused on guidelines concerning the collection, analysis, interpretation, and reporting of PRO data. However, we recommend the application of appropriate PRO instruments, with respect to its content and measurement properties (ie, research question, content validity, and other measurement properties), in brain tumour research. PROs should be well defined and reliable to generate high-quality evidence, and our recommendations on the use of specific PRO measures could help to improve the quality of PRO evidence derived from neuro-oncological studies, and might add a new dimension in how the value of therapeutics is assessed in patients with brain tumours. In this Policy Review, we present the RANO-PRO working plan for the use of PROs in adults with brain tumours.

Original languageEnglish (US)
Pages (from-to)e173-e180
JournalThe Lancet Oncology
Volume19
Issue number3
DOIs
StatePublished - Mar 1 2018

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Brain Neoplasms
Research
Patient Reported Outcome Measures
Administrative Personnel
Decision Making
Outcome Assessment (Health Care)
Clinical Trials
Guidelines
Physicians
Survival
Therapeutics

ASJC Scopus subject areas

  • Oncology

Cite this

Working plan for the use of patient-reported outcome measures in adults with brain tumours : a Response Assessment in Neuro-Oncology (RANO) initiative. / Dirven, Linda; Armstrong, Terri S.; Blakeley, Jaishri; Brown, Paul D.; Grant, Robin; Jalali, Rakesh; Leeper, Heather; Mendoza, Tito; Nayak, Lakshmi; Reijneveld, Jaap C.; Rhun, Emilie Le; Walbert, Tobias; Weller, Michael; Wen, Patrick Y.; Taphoorn, Martin J.B.

In: The Lancet Oncology, Vol. 19, No. 3, 01.03.2018, p. e173-e180.

Research output: Contribution to journalReview article

Dirven, L, Armstrong, TS, Blakeley, J, Brown, PD, Grant, R, Jalali, R, Leeper, H, Mendoza, T, Nayak, L, Reijneveld, JC, Rhun, EL, Walbert, T, Weller, M, Wen, PY & Taphoorn, MJB 2018, 'Working plan for the use of patient-reported outcome measures in adults with brain tumours: a Response Assessment in Neuro-Oncology (RANO) initiative', The Lancet Oncology, vol. 19, no. 3, pp. e173-e180. https://doi.org/10.1016/S1470-2045(18)30004-4
Dirven, Linda ; Armstrong, Terri S. ; Blakeley, Jaishri ; Brown, Paul D. ; Grant, Robin ; Jalali, Rakesh ; Leeper, Heather ; Mendoza, Tito ; Nayak, Lakshmi ; Reijneveld, Jaap C. ; Rhun, Emilie Le ; Walbert, Tobias ; Weller, Michael ; Wen, Patrick Y. ; Taphoorn, Martin J.B. / Working plan for the use of patient-reported outcome measures in adults with brain tumours : a Response Assessment in Neuro-Oncology (RANO) initiative. In: The Lancet Oncology. 2018 ; Vol. 19, No. 3. pp. e173-e180.
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