Workgroup report: Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity into International Hazard and Risk Assessment Strategies

Sandra Coecke, Alan M. Goldberg, Sandra Allen, Leonora Buzanska, Gemma Calamandrei, Kevin Crofton, Lars Hareng, Thomas Hartung, Holger Knaut, Paul Honegger, Miriam Jacobs, Pamela Lein, Abby Li, William Mundy, David Owen, Steffen Schneider, Ellen Silbergeld, Torsten Reum, Tomas Trnovec, Florianne Monnet-TschudiAnna Bal-Price

Research output: Contribution to journalArticle

Abstract

This is the report of the first workshop on Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity (DNT) Testing into International Hazard and Risk Assessment Strategies, held in Ispra, Italy, on 19-21 April 2005. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and jointly organized by ECVAM, the European Chemical Industry Council, and the Johns Hopkins University Center for Alternatives to Animal Testing. The primary aim of the workshop was to identify and catalog potential methods that could be used to assess how data from in vitro alternative methods could help to predict and identify DNT hazards. Working groups focused on two different aspects. a) details on the science available in the field of DNT, including discussions on the models available to capture the critical DNT mechanisms and processes, and b) policy and strategy aspects to assess the integration of alternative methods in a regulatory framework. This report summarizes these discussions and details the recommendations and priorities for future work.

Original languageEnglish (US)
Pages (from-to)924-931
Number of pages8
JournalEnvironmental health perspectives
Volume115
Issue number6
DOIs
StatePublished - Jun 2007

Keywords

  • High-throughput screening
  • In vitro developmental neurotoxicity models
  • Regulatory use
  • Validation

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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    Coecke, S., Goldberg, A. M., Allen, S., Buzanska, L., Calamandrei, G., Crofton, K., Hareng, L., Hartung, T., Knaut, H., Honegger, P., Jacobs, M., Lein, P., Li, A., Mundy, W., Owen, D., Schneider, S., Silbergeld, E., Reum, T., Trnovec, T., ... Bal-Price, A. (2007). Workgroup report: Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity into International Hazard and Risk Assessment Strategies. Environmental health perspectives, 115(6), 924-931. https://doi.org/10.1289/ehp.9427