Abstract
Background: The Framingham risk estimation (FRE) serves as the basis for identifying which asymptomatic adults should be treated with aspirin and lipid-lowering therapy in primary prevention. However, the FRE generally yields low estimates of 10-year "hard" coronary heart disease (CHD) event risk with few women (20%) (n = 0). Significant subclinical atherosclerosis was defined as age-sex adjusted >75th percentile CAC scores. Results: Ninety-eight percent were at low risk (mean FRE of only 2% ± 2%). However, 40% had detectable CAC, 12% had CAC >100, and 6% had CAC ≥400. Based on CAC score percentiles, 32% had significant subclinical atherosclerosis and 17% ranked above the 90th percentile. Conclusion: Among women classified as low risk by FRE, a third had significant subclinical atherosclerosis. Sisters of probands with premature CHD appear to be a high-risk group and may warrant noninvasive screening for subclinical atherosclerosis to appropriately target individuals for more aggressive primary prevention therapy than what is currently recommended.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1276-1281 |
| Number of pages | 6 |
| Journal | American Heart Journal |
| Volume | 150 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2005 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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Women with a low Framingham risk score and a family history of premature coronary heart disease have a high prevalence of subclinical coronary atherosclerosis. / Michos, Erin Donnelly; Vasamreddy, Chandrasekhar R.; Becker, Diane M; Yanek, Lisa; Moy, Taryn F.; Fishman, Elliot K; Becker, Lewis; Blumenthal, Roger S.
In: American Heart Journal, Vol. 150, No. 6, 12.2005, p. 1276-1281.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Women with a low Framingham risk score and a family history of premature coronary heart disease have a high prevalence of subclinical coronary atherosclerosis
AU - Michos, Erin Donnelly
AU - Vasamreddy, Chandrasekhar R.
AU - Becker, Diane M
AU - Yanek, Lisa
AU - Moy, Taryn F.
AU - Fishman, Elliot K
AU - Becker, Lewis
AU - Blumenthal, Roger S
PY - 2005/12
Y1 - 2005/12
N2 - Background: The Framingham risk estimation (FRE) serves as the basis for identifying which asymptomatic adults should be treated with aspirin and lipid-lowering therapy in primary prevention. However, the FRE generally yields low estimates of 10-year "hard" coronary heart disease (CHD) event risk with few women (20%) (n = 0). Significant subclinical atherosclerosis was defined as age-sex adjusted >75th percentile CAC scores. Results: Ninety-eight percent were at low risk (mean FRE of only 2% ± 2%). However, 40% had detectable CAC, 12% had CAC >100, and 6% had CAC ≥400. Based on CAC score percentiles, 32% had significant subclinical atherosclerosis and 17% ranked above the 90th percentile. Conclusion: Among women classified as low risk by FRE, a third had significant subclinical atherosclerosis. Sisters of probands with premature CHD appear to be a high-risk group and may warrant noninvasive screening for subclinical atherosclerosis to appropriately target individuals for more aggressive primary prevention therapy than what is currently recommended.
AB - Background: The Framingham risk estimation (FRE) serves as the basis for identifying which asymptomatic adults should be treated with aspirin and lipid-lowering therapy in primary prevention. However, the FRE generally yields low estimates of 10-year "hard" coronary heart disease (CHD) event risk with few women (20%) (n = 0). Significant subclinical atherosclerosis was defined as age-sex adjusted >75th percentile CAC scores. Results: Ninety-eight percent were at low risk (mean FRE of only 2% ± 2%). However, 40% had detectable CAC, 12% had CAC >100, and 6% had CAC ≥400. Based on CAC score percentiles, 32% had significant subclinical atherosclerosis and 17% ranked above the 90th percentile. Conclusion: Among women classified as low risk by FRE, a third had significant subclinical atherosclerosis. Sisters of probands with premature CHD appear to be a high-risk group and may warrant noninvasive screening for subclinical atherosclerosis to appropriately target individuals for more aggressive primary prevention therapy than what is currently recommended.
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UR - http://www.scopus.com/inward/citedby.url?scp=28844499541&partnerID=8YFLogxK
U2 - 10.1016/j.ahj.2005.02.037
DO - 10.1016/j.ahj.2005.02.037
M3 - Article
VL - 150
SP - 1276
EP - 1281
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 6
ER -