Wolbachia invades Anopheles stephensi populations and induces refractoriness to Plasmodium infection

Guowu Bian, Deepak Joshi, Yuemei Dong, Peng Lu, Guoli Zhou, Xiaoling Pan, Yao Xu, George Dimopoulos, Zhiyong Xi

Research output: Contribution to journalArticle

Abstract

Wolbachia is a maternally transmitted symbiotic bacterium of insects that has been proposed as a potential agent for the control of insect-transmitted diseases. One of the major limitations preventing the development of Wolbachia for malaria control has been the inability to establish inherited infections of Wolbachia in anopheline mosquitoes. Here, we report the establishment of a stable Wolbachia infection in an important malaria vector, Anopheles stephensi. In A. stephensi, Wolbachia strain wAlbB displays both perfect maternal transmission and the ability to induce high levels of cytoplasmic incompatibility. Seeding of naturally uninfected A. stephensi populations with infected females repeatedly resulted in Wolbachia invasion of laboratory mosquito populations. Furthermore, wAlbB conferred resistance in the mosquito to the human malaria parasite Plasmodium falciparum.

Original languageEnglish (US)
Pages (from-to)748-751
Number of pages4
JournalScience
Volume340
Issue number6133
DOIs
StatePublished - 2013

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Wolbachia
Anopheles
Malaria
Culicidae
Population
Insect Control
Falciparum Malaria
Infection
Insects
Parasites
Mothers
Bacteria

ASJC Scopus subject areas

  • General

Cite this

Bian, G., Joshi, D., Dong, Y., Lu, P., Zhou, G., Pan, X., ... Xi, Z. (2013). Wolbachia invades Anopheles stephensi populations and induces refractoriness to Plasmodium infection. Science, 340(6133), 748-751. https://doi.org/10.1126/science.1236192

Wolbachia invades Anopheles stephensi populations and induces refractoriness to Plasmodium infection. / Bian, Guowu; Joshi, Deepak; Dong, Yuemei; Lu, Peng; Zhou, Guoli; Pan, Xiaoling; Xu, Yao; Dimopoulos, George; Xi, Zhiyong.

In: Science, Vol. 340, No. 6133, 2013, p. 748-751.

Research output: Contribution to journalArticle

Bian, G, Joshi, D, Dong, Y, Lu, P, Zhou, G, Pan, X, Xu, Y, Dimopoulos, G & Xi, Z 2013, 'Wolbachia invades Anopheles stephensi populations and induces refractoriness to Plasmodium infection', Science, vol. 340, no. 6133, pp. 748-751. https://doi.org/10.1126/science.1236192
Bian, Guowu ; Joshi, Deepak ; Dong, Yuemei ; Lu, Peng ; Zhou, Guoli ; Pan, Xiaoling ; Xu, Yao ; Dimopoulos, George ; Xi, Zhiyong. / Wolbachia invades Anopheles stephensi populations and induces refractoriness to Plasmodium infection. In: Science. 2013 ; Vol. 340, No. 6133. pp. 748-751.
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