WNT16 induces proliferation and osteogenic differentiation of human perivascular stem cells

Carolyn A. Meyers, Jia Shen, Amy Lu, Aaron W. James

Research output: Contribution to journalArticlepeer-review

Abstract

Perivascular stem cells (PSC) are a progenitor population defined by their perivascular residence. Recent studies have examined the relative difference in Wnt ligands to induce PSC differentiation, including Wnt16. Here, we examine the role of Wnt16 in the proliferation and osteogenic differentiation of human PSC. Treatment of PSC with WNT16 significantly increased cell proliferation to a greater extent than did WNT3A. In addition, WNT16 showed a significant increase in osteogenic gene expression among PSC. These data demonstrate that WNT16 represents a combined mitogenic/pro-osteogenic stimulus that may play a functional role in human mesenchymal stem cell mediated bone repair.

Original languageEnglish (US)
Pages (from-to)854-857
Number of pages4
JournalJournal of Orthopaedics
Volume15
Issue number3
DOIs
StatePublished - Sep 2018

Keywords

  • DKK1
  • Osteogenesis
  • PSC
  • Perivascular stem cell
  • WNT3A
  • Wnt signaling

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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