Wnt signaling in human development: Beta-catenin nuclear translocation in fetal lung, kidney, placenta, capillaries, adrenal, and cartilage

Research output: Contribution to journalArticlepeer-review

Abstract

The Wnt signaling pathway is involved in both normal development and tumorigenesis. Activation of the pathway results in stabilization and nuclear translocation of beta-catenin protein. Nuclear localization of beta-catenin has been used to identify tumors in which mutations in APC or beta-catenin activate Wnt signaling. We analyzed the subcellular localization of beta-catenin immunohistochemically in human fetal and postnatal tissues to identify activation of Wnt signaling during development. Nuclear beta-catenin is present in capillary endothelium, mesenchyme surrounding renal tubules, adrenal cortex, cartilage anlage, placental cytotrophoblast, and pulmonary acinar buds. These investigations suggest a defined role for Wnt signaling in human fetal development and provide a catalogue of non-neoplastic tissues with nuclear beta-catenin staining.

Original languageEnglish (US)
Pages (from-to)351-357
Number of pages7
JournalPediatric and Developmental Pathology
Volume4
Issue number4
DOIs
StatePublished - Aug 14 2001

Keywords

  • Beta-catenin
  • Development
  • Immunohistochemistry
  • Wnt

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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