Within-meal gut feedback signaling

Research output: Contribution to journalArticle

Abstract

During a meal, multiple gastrointestinal sites are stimulated by ingested nutrients and their digestion products, initiating local gastrointestinal actions and producing a variety of potential feedback signals that can contribute to meal termination. During ingestion, gastric emptying is rapid, allowing a significant portion of ingested nutrients to enter the intestine. Gastric and duodenal vagal afferent fibers increase their electrophysiological activity in relation to the mechanical presence of ingested nutrients. On reaching the duodenum, nutrients also activate vagal chemosensitive elements and stimulate the release of a variety of brain gut peptides including cholecystokinin (CCK). CCK also activates vagal afferent fibers directly and modifies the response properties of vagal mechanosensitive fibers to gastric and duodenal loads. Blocking or eliminating these feedback signals results in increased meal size demonstrating their role in meal termination.

Original languageEnglish (US)
JournalInternational Journal of Obesity
Volume25
Issue numberSUPPL. 5
DOIs
StatePublished - 2001

Fingerprint

Meals
digestive system
Food
cholecystokinin
dietary fiber
Cholecystokinin
nutrients
Stomach
stomach
portion size
gastric emptying
Gastric Emptying
duodenum
Duodenum
Intestines
Digestion
intestines
Eating
digestion
ingestion

Keywords

  • Cholecystokinin
  • Gastric emptying
  • Meal size
  • OLETF
  • Vagal afferents

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Within-meal gut feedback signaling. / Moran, Timothy H; Ladenheim, Ellen Elizabeth; Schwartz, G. J.

In: International Journal of Obesity, Vol. 25, No. SUPPL. 5, 2001.

Research output: Contribution to journalArticle

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