TY - JOUR
T1 - Wiring the angiogenic switch
T2 - Ras, myc, and thrombospondin-1
AU - Volpert, Olga V.
AU - Alani, Rhoda M.
PY - 2003/3
Y1 - 2003/3
N2 - The formation of a blood supply is critical for tumor growth and metastasis; however, understanding the relationship of cellular transformation to tumor angiogenesis has been limited by the multifactorial nature of both processes. In this issue of Cancer Cell, Watnick and colleagues use a genetically defined tumor model system to determine the link between ras, myc, and angiogenesis and identify Thrombospondin-1 as being the critical regulator of angiogenesis in this system (Watnick et al., 2003).
AB - The formation of a blood supply is critical for tumor growth and metastasis; however, understanding the relationship of cellular transformation to tumor angiogenesis has been limited by the multifactorial nature of both processes. In this issue of Cancer Cell, Watnick and colleagues use a genetically defined tumor model system to determine the link between ras, myc, and angiogenesis and identify Thrombospondin-1 as being the critical regulator of angiogenesis in this system (Watnick et al., 2003).
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U2 - 10.1016/S1535-6108(03)00056-4
DO - 10.1016/S1535-6108(03)00056-4
M3 - Article
C2 - 12676576
AN - SCOPUS:0041785511
SN - 1535-6108
VL - 3
SP - 199
EP - 200
JO - Cancer Cell
JF - Cancer Cell
IS - 3
ER -