Wind direction and proximity to larval sites determines malaria risk in Kilifi District in Kenya

Janet T. Midega, Dave L. Smith, Ally Olotu, Joseph M. Mwangangi, Joseph G. Nzovu, Juliana Wambua, George Nyangweso, Charles M. Mbogo, George K. Christophides, Kevin Marsh, Philip Bejon

Research output: Contribution to journalArticle

Abstract

Studies of the fine-scale spatial epidemiology of malaria consistently identify malaria hotspots, comprising clusters of homesteads at high transmission intensity. These hotspots sustain transmission, and may be targeted by malaria-control programmes. Here we describe the spatial relationship between the location of Anopheles larval sites and human malaria infection in a cohort study of 642 children, aged 1-10-years-old. Our data suggest that proximity to larval sites predict human malaria infection, when homesteads are upwind of larval sites, but not when homesteads are downwind of larval sites. We conclude that following oviposition, female Anophelines fly upwind in search for human hosts and, thus, malaria transmission may be disrupted by targeting vector larval sites in close proximity, and downwind to malaria hotspots.

Original languageEnglish (US)
Article number674
JournalNature Communications
Volume3
DOIs
StatePublished - 2012

Fingerprint

Kenya
wind direction
Malaria
proximity
infectious diseases
Malaria control
epidemiology
Epidemiology
Oviposition
Anopheles
Infection
Direction compound
Cohort Studies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Midega, J. T., Smith, D. L., Olotu, A., Mwangangi, J. M., Nzovu, J. G., Wambua, J., ... Bejon, P. (2012). Wind direction and proximity to larval sites determines malaria risk in Kilifi District in Kenya. Nature Communications, 3, [674]. https://doi.org/10.1038/ncomms1672

Wind direction and proximity to larval sites determines malaria risk in Kilifi District in Kenya. / Midega, Janet T.; Smith, Dave L.; Olotu, Ally; Mwangangi, Joseph M.; Nzovu, Joseph G.; Wambua, Juliana; Nyangweso, George; Mbogo, Charles M.; Christophides, George K.; Marsh, Kevin; Bejon, Philip.

In: Nature Communications, Vol. 3, 674, 2012.

Research output: Contribution to journalArticle

Midega, JT, Smith, DL, Olotu, A, Mwangangi, JM, Nzovu, JG, Wambua, J, Nyangweso, G, Mbogo, CM, Christophides, GK, Marsh, K & Bejon, P 2012, 'Wind direction and proximity to larval sites determines malaria risk in Kilifi District in Kenya', Nature Communications, vol. 3, 674. https://doi.org/10.1038/ncomms1672
Midega, Janet T. ; Smith, Dave L. ; Olotu, Ally ; Mwangangi, Joseph M. ; Nzovu, Joseph G. ; Wambua, Juliana ; Nyangweso, George ; Mbogo, Charles M. ; Christophides, George K. ; Marsh, Kevin ; Bejon, Philip. / Wind direction and proximity to larval sites determines malaria risk in Kilifi District in Kenya. In: Nature Communications. 2012 ; Vol. 3.
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