Willingness to participate in AIDS vaccine trials among high-risk populations in northern Thailand

David D. Celentano, Chris Beyrer, Chawalit Natpratan, Sakol Eiumtrakul, Linda Sussman, Philip O. Renzullo, Chirasak Khamboonruang, Kenrad E. Nelson

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To determine the anticipated participation in a prophylactic AIDS vaccine trial and to identify perceived benefits and barriers to enrollment of HIV-seronegative volunteers at risk of HIV infection in northern Thailand. Design: A cross-sectional survey. Methods: Subjects interviewed in a cross-sectional survey included female commercial sex workers (n = 215), men attending sexually transmitted disease clinics (n = 219), conscripts in the Royal Thai Army (n = 1453), and men discharged from the army (n = 293) who had returned to civilian life. We determined AIDS vaccine knowledge and attitudes, perceived vulnerability to HIV infection, barriers and incentives to participate in a future vaccine trial and agreement to participate in a randomized trial. Results: Awareness of vaccines (88-97%) and AIDS vaccine development efforts (62-77%) were common and viewed to be a complement to behavior change (74-94%). Approximately 25% of subjects would definitely join a trial if asked, and an additional 38% would accept an AIDS vaccine if they were convinced it would be safe and effective. Important barriers to participation included concerns with discrimination (16-45%), short- (37-60%) and long-term (30-55%) vaccine side-effects, fear of disability and death (36-58%), and beliefs that partners would refuse to have sex (24-49%) after immunization. The principal inducement to join a trial was health insurance (62%). Conclusion: Potential HIV vaccine trial participants have several fears of joining a vaccine study at this time. Information derived from Phase I/II trials is needed to address these concerns if enrollment in efficacy trials is to be successful in the near future.

Original languageEnglish (US)
Pages (from-to)1079-1083
Number of pages5
JournalAIDS
Volume9
Issue number9
DOIs
StatePublished - Sep 1995

Keywords

  • AIDS vaccines
  • HIV/AIDS
  • Human volunteers
  • Prophylactic trials
  • Prostitution
  • Risk factors
  • Sexually transmitted diseases
  • Thailand

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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