Will seizure control improve by switching from the modified Atkins diet to the traditional ketogenic diet?

Eric H. Kossoff, Jennifer L. Bosarge, Maria J. Miranda, Adelheid Wiemer-Kruel, Hoon Chul Kang, Heung Dong Kim

Research output: Contribution to journalArticle

Abstract

It has been reported that children can maintain seizure control when the ketogenic diet (KD) is transitioned to the less-restrictive modified Atkins diet (MAD). What is unknown, however, is the likelihood of additional seizure control from a switch from the MAD to the KD. Retrospective information was obtained from 27 patients who made this dietary change from four different institutions. Ten (37%) patients had ≥10% additional seizure reduction with the KD over the MAD, of which five became seizure-free. The five children who did not improve on the MAD failed to improve when transitioned to the KD. A higher incidence of improvement with the KD occurred for those with myoclonic-astatic epilepsy (70% vs. 12% for all other etiologies, p = 0.004), including all who became seizure-free. These results suggest that the KD probably represents a "higher dose" of dietary therapy than the MAD, which may particularly benefit those with myoclonic-astatic epilepsy.

Original languageEnglish (US)
Pages (from-to)2496-2499
Number of pages4
JournalEpilepsia
Volume51
Issue number12
DOIs
StatePublished - Dec 1 2010

Keywords

  • Doose
  • Epilepsy
  • Intractable
  • Ketogenic
  • Modified Atkins
  • Myoclonic astatic

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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