Wild-derived inbred mouse strains have short telomeres

Michael T. Hemann, Carol W. Greider

Research output: Contribution to journalArticle


Telomere length and telomerase activity directly affect the replicative capacity of primary human cells. Some have suggested that telomere length influences organismal lifespan. We compared telomere length distributions in a number of inbred and outbred established mouse strains with those of strains recently derived from wild mice. Telomere length was considerably shorter in wild-derived strains than in the established strains. We found no correlation of telomere length with lifespan, even among closely related inbred mouse strains. Thus, while telomere length plays a role in cellular lifespan in cultured human cells, it is not a major factor in determining organismal lifespan.

Original languageEnglish (US)
Pages (from-to)4474-4478
Number of pages5
JournalNucleic acids research
Issue number22
StatePublished - Nov 15 2000

ASJC Scopus subject areas

  • Genetics

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