TY - JOUR
T1 - Widespread pain among youth with sickle cell disease hospitalized with vasoocclusive pain
AU - Zempsky, William T.
AU - Wakefield, Emily O.
AU - Santanelli, James P.
AU - New, Tamara
AU - Smith-Whitley, Kimberly
AU - Casella, James F.
AU - Palermo, Tonya M.
N1 - Publisher Copyright:
© 2016 Wolters Kluwer Health, Inc.
PY - 2017
Y1 - 2017
N2 - Objectives: The purpose of this study was to describe the clinical phenotype of widespread pain (WSP) among youth with sickle cell disease (SCD) hospitalized with vasoocclusive pain. Materials and Methods: One hundred fifty-six youth with SCD, between 7 and 21 years of age hospitalized at 4 children's hospitals for a vasoocclusive episode were evaluated. Data were collected during 1 day of the hospitalization. Results: Using the 2010 American College of Rheumatology guidelines, 21.8% of patients were identified as having WSP (pain in 7 or more unique body locations). Patients classified as having WSP had higher pain intensity (6.5 vs. 5.6; t=2.19, P=0.03) higher pain burden (13.0 vs. 9.8; t=3.09, P=0.002), higher acute functional disability (22.1 vs. 16.5; t=2.43, P=0.016), higher chronic functional disability (30.4 vs. 22.2; t=2.31, P=0.02), lower positive affect (22.9 vs. 27.6; t=2.23, P=0.027), and lower quality of life (56.2 vs. 62.9; t=1.99, P=0.049) than those youth with SCD without WSP. Discussion: Assessment of WSP may identify a unique clinical phenotype of youth with SCD with differing treatment needs.
AB - Objectives: The purpose of this study was to describe the clinical phenotype of widespread pain (WSP) among youth with sickle cell disease (SCD) hospitalized with vasoocclusive pain. Materials and Methods: One hundred fifty-six youth with SCD, between 7 and 21 years of age hospitalized at 4 children's hospitals for a vasoocclusive episode were evaluated. Data were collected during 1 day of the hospitalization. Results: Using the 2010 American College of Rheumatology guidelines, 21.8% of patients were identified as having WSP (pain in 7 or more unique body locations). Patients classified as having WSP had higher pain intensity (6.5 vs. 5.6; t=2.19, P=0.03) higher pain burden (13.0 vs. 9.8; t=3.09, P=0.002), higher acute functional disability (22.1 vs. 16.5; t=2.43, P=0.016), higher chronic functional disability (30.4 vs. 22.2; t=2.31, P=0.02), lower positive affect (22.9 vs. 27.6; t=2.23, P=0.027), and lower quality of life (56.2 vs. 62.9; t=1.99, P=0.049) than those youth with SCD without WSP. Discussion: Assessment of WSP may identify a unique clinical phenotype of youth with SCD with differing treatment needs.
KW - centralized pain
KW - hospitalization
KW - sickle cell disease
KW - vasoocclusive episode
KW - widespread pain
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U2 - 10.1097/AJP.0000000000000403
DO - 10.1097/AJP.0000000000000403
M3 - Article
C2 - 27322398
AN - SCOPUS:84975502321
SN - 0749-8047
VL - 33
SP - 335
EP - 339
JO - Clinical Journal of Pain
JF - Clinical Journal of Pain
IS - 4
ER -