Why is pancreatic cancer so deadly? The pathologist's view

Ralph H. Hruban, Matthias M. Gaida, Elizabeth Thompson, Seung Mo Hong, Michaël Noë, Lodewijk A.A. Brosens, Martine Jongepier, G. Johan A. Offerhaus, Laura D. Wood

Research output: Contribution to journalArticlepeer-review


The remarkable aggressiveness of pancreatic cancer has never been fully explained. Although clearly multifactorial, we postulate that venous invasion, a finding seen in most pancreatic cancers but not in most cancers of other organs, may be a significant, underappreciated contributor to the aggressiveness of this disease.

Original languageEnglish (US)
Pages (from-to)131-141
Number of pages11
JournalJournal of Pathology
Issue number2
StatePublished - Jun 2019


  • pancreas
  • pancreas cancer
  • pancreatic cancer
  • prognosis
  • tumor immune microenvironment
  • vein
  • venous invasion

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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