Why is cancer drug discovery so difficult?

Alexander Kamb, Susan Wee, Christoph Lengauer

Research output: Contribution to journalArticle

Abstract

Thirty-five years after the 'war on cancer' was declared, the discovery of anticancer drugs remains a highly challenging endeavour. Here, we consider the factors responsible, such as tumour heterogeneity, and suggest strategies to improve the chances of short-term success in the development of novel anticancer drugs.

Original languageEnglish (US)
Pages (from-to)115-120
Number of pages6
JournalNature Reviews Drug Discovery
Volume6
Issue number2
DOIs
StatePublished - Feb 2007
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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