Why is cancer drug discovery so difficult?

Alexander Kamb; Susan Wee; Christoph Lengauer

doi:10.1038/nrd2155

Why is cancer drug discovery so difficult?

Alexander Kamb, Susan Wee, Christoph Lengauer

Research output: Contribution to journal › Article › peer-review

254 Scopus citations

Abstract

Thirty-five years after the 'war on cancer' was declared, the discovery of anticancer drugs remains a highly challenging endeavour. Here, we consider the factors responsible, such as tumour heterogeneity, and suggest strategies to improve the chances of short-term success in the development of novel anticancer drugs.

Original language	English (US)
Pages (from-to)	115-120
Number of pages	6
Journal	Nature Reviews Drug Discovery
Volume	6
Issue number	2
DOIs	https://doi.org/10.1038/nrd2155
State	Published - Feb 2007
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

Access to Document

10.1038/nrd2155

Cite this

@article{938176fb2bd4406f94dff4a9775b6de9,

title = "Why is cancer drug discovery so difficult?",

abstract = "Thirty-five years after the 'war on cancer' was declared, the discovery of anticancer drugs remains a highly challenging endeavour. Here, we consider the factors responsible, such as tumour heterogeneity, and suggest strategies to improve the chances of short-term success in the development of novel anticancer drugs.",

author = "Alexander Kamb and Susan Wee and Christoph Lengauer",

year = "2007",

month = feb,

doi = "10.1038/nrd2155",

language = "English (US)",

volume = "6",

pages = "115--120",

journal = "Nature Reviews Drug Discovery",

issn = "1474-1776",